Porous Polymer Bearing Polyphenolic Organic Building Units as a Chemotherapeutic Agent for Cancer Treatment

ACS Omega
Piyali BhanjaAsim Bhaumik

Abstract

Cancer is one of the most deadly diseases worldwide. Although several chemotherapeutic agents are available at present for its treatment, they have their own limitations. The main problems of these chemotherapeutic agents are cost involvement and severe life-threatening antagonistic effects. Here, we report a new biodegradable N-rich porous organic polymer methylenedianiline-triformyl phloroglucinol (MDTFP-1) synthesized via a Schiff base condensation reaction between two reactive monomers, that is, 4,4'-methylenedianiline and 2,4,6-triformyl phloroglucinol under inert atmosphere. Because this porous polymer contains polyphenolic building units and has a high Brunauer-Emmett-Teller surface area (283 m2 g-1), it has been explored in the anticancer activity using HCT 116, A549, and MIA PaCa-2 cell lines. We have carried out the flow cytometric assessment using Annexin-V-FITC/PI staining through the exposed level of phosphatidylserine in the outer membrane of cells with MDTFP-1-induced apoptosis. Our results suggested that apoptosis of cells have been enhanced in a time-dependent manner in the presence of this novel porous polymer.

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Citations

Jul 28, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyu LiuManzhou Zhu
Oct 6, 2021·Chemical Society Reviews·Nem SinghJong Seung Kim

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Methods Mentioned

BETA
X-ray
transmission electron
NMR
flow cytometry
ELISA

Software Mentioned

FlowJo
Autosorb

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