Porous polymer coatings on metal microneedles for enhanced drug delivery

Royal Society Open Science
Asad UllahGyu Man Kim

Abstract

We present a simple method to coat microneedles (MNs) uniformly with a porous polymer (PLGA) that can deliver drugs at high rates. Stainless steel (SS) MNs of high mechanical strength were coated with a thin porous polymer layer to enhance their delivery rates. Additionally, to improve the interfacial adhesion between the polymer and MNs, the MN surface was modified by plasma treatment followed by dip coating with polyethyleneimine, a polymer with repeating amine units. The average failure load (the minimum force sufficient for detaching the polymer layer from the surface of SS) recorded for the modified surface coating was 25 N, whereas it was 2.2 N for the non-modified surface. Calcein dye was successfully delivered into porcine skin to a depth of 750 µm by the porous polymer-coated MNs, demonstrating that the developed MNs can pierce skin easily without deformation of MNs; additional skin penetration tests confirmed this finding. For visual comparison, rhodamine B dye was delivered using porous-coated and non-coated MNs in gelatin gel which showed that delivery with porous-coated MNs penetrate deeper when compared with non-coated MNs. Finally, lidocaine and rhodamine B dye were delivered in phosphate-buffered saline (PBS) me...Continue Reading

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Citations

Oct 31, 2019·Dose-response : a Publication of International Hormesis Society·Xiaoxiang HeDaming Wu
Nov 17, 2019·Journal of Personalized Medicine·Liliana R PiresJoão Gaspar
Jun 21, 2019·Royal Society Open Science·Yucheng ChangJianling Zhao
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Sep 3, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·André F MoreiraIlídio J Correia
Jan 30, 2021·Nature Communications·Shinya KusamaMatsuhiko Nishizawa
Aug 21, 2021·Drug Delivery and Translational Research·Leilei BaoBeomjoon Kim
Nov 10, 2021·Biomaterials Science·Shuyao RuanNianping Feng

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