Porous polymer monolith for surface-enhanced laser desorption/ionization time-of-flight mass spectrometry of small molecules

Rapid Communications in Mass Spectrometry : RCM
Dominic S PetersonJean M Fréchet

Abstract

Porous poly(butyl methacrylate-co-ethylene dimethacrylate), poly(benzyl methacrylate-co-ethylene dimethacrylate), and poly(styrene-co-divinylbenzene) monoliths have been prepared on the top of standard sample plates used for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry and the modified plates were used for laser desorption/ionization mass spectrometry (LDI-MS). The hydrophobic porous surface of these monoliths enables the transfer of sufficient energy to the analyte to induce desorption and ionization prior to TOFMS analysis. Both UV and thermally initiated polymerization using a mask or circular openings in a thin gasket have been used to define spot locations matching those of the MALDI plates. The desorption/ionization ability of the monolithic materials depends on the applied laser power, the solvent used for sample preparation, and the pore size of the monoliths. The monolithic matrices are very stable and can be used even after long storage times in a typical laboratory environment without observing any deterioration of their properties. The performance of the monolithic material is demonstrated with the mass analysis of several small molecules including drugs, explosives, and a...Continue Reading

Citations

Mar 7, 2012·Journal of the American Society for Mass Spectrometry·Nina Aminlashgari, Minna Hakkarainen
Mar 20, 2009·Journal of the American Society for Mass Spectrometry·Nahid AminiGunnar Thorsén
Aug 31, 2010·Analytical Chemistry·Ranu Nayak, Daniel R Knapp
Nov 1, 2007·Chemical Communications : Chem Comm·Ying ZhangPengyuan Yang
Feb 1, 2006·Expert Review of Proteomics·Andrew M Dattelbaum, Srinivas Iyer
Dec 6, 2008·Journal of Separation Science·Frantisek Svec
Jul 27, 2007·Rapid Communications in Mass Spectrometry : RCM·Muhammad Ahsan HashirGuenther K Bonn
Nov 23, 2007·Mass Spectrometry Reviews·Annette S FangJames N Kyranos
Sep 13, 2006·Mass Spectrometry Reviews·Dominic S Peterson
Sep 10, 2004·Journal of Chromatography. a·Emily F HilderJean M J Fréchet
Jul 10, 2012·Analytica Chimica Acta·Jeongwook LeeWoon-Seok Yeo
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Feb 1, 2021·Analytica Chimica Acta·Thomas ThemelisSebastiaan Eeltink
Apr 4, 2021·Polymers·Evgenia Korzhikova-VlakhTatiana Tennikova
Jun 3, 2008·Analytical Chemistry·Mohammadreza ShariatgorjiLeopold L Ilag
Jan 14, 2009·Analytical Chemistry·Hongyan BiHubert H Girault
Jun 27, 2008·Analytical Chemistry·Jamie D DunnMerlin L Bruening

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