PMID: 11920760Mar 29, 2002Paper

Porous resins as a cavitation enhancer for low-frequency sonophoresis

Journal of Pharmaceutical Sciences
T TeraharaR Langer

Abstract

The application of low-frequency ultrasound enhances drug transport through the skin, a phenomenon referred to as low-frequency sonophoresis. This enhancement is mediated through cavitation, the formation and collapse of gaseous bubbles. We hypothesized that the efficacy of low-frequency sonophoresis can be significantly enhanced by provision of nuclei for cavitation. In this study, we used two porous resins, Diaion HP20 and Diaion HP2MG (2MG), as cavitation nuclei. We measured the effect of these resins on cavitation using pitting of aluminum foil. 2MG showed a higher efficacy in enhancing cavitation compared with Diaion HP20. 2MG was also effective in enhancing transdermal mannitol transport. These results confirm that the addition of cavitation nuclei such as porous resins further increases the effect of low-frequency ultrasound on skin permeability.

References

Sep 1, 1991·The Journal of the Acoustical Society of America·S I Madanshetty, R E Apfel
Sep 1, 1991·The Journal of the Acoustical Society of America·S I MadanshettyR E Apfel
Nov 1, 1990·The Journal of the Acoustical Society of America·C K Holland, R E Apfel
Jun 1, 1995·Journal of Pharmaceutical Sciences·S MitragotriR Langer
Aug 11, 1995·Science·S MitragotriR Langer
Jul 1, 1996·Journal of Pharmaceutical Sciences·M E JohnsonR Langer
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MitragotriR Langer

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Citations

Mar 17, 2004·Advanced Drug Delivery Reviews·Samir Mitragotri, Joseph Kost
Jul 22, 2004·American Journal of Therapeutics·Victor M Meidan, Bozena B Michniak
Jan 28, 2014·Advanced Drug Delivery Reviews·Aharon AzaguryJoseph Kost
Jun 12, 2014·Ultrasonics Sonochemistry·Mai Aldwaikat, Mohammed Alarjah
Aug 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyle T RichT Douglas Mast
Jan 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Jan 2, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilana LavonGiora Enden
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhong-Gao GaoNatalya Rapoport
Sep 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilana LavonJoseph Kost
Mar 14, 2017·Scientific Reports·Tatiana Aparecida PereiraRenata F V Lopez
Mar 10, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Christopher J RasmussenAlexander V Neimark
Jul 27, 2021·Ultrasound in Medicine & Biology·Lixia Mei, Zhen Zhang

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