Porous titanium bases for osteochondral tissue engineering

Acta Biomaterialia
Adam B NoverClark T Hung

Abstract

Tissue engineering of osteochondral grafts may offer a cell-based alternative to native allografts, which are in short supply. Previous studies promote the fabrication of grafts consisting of a viable cell-seeded hydrogel integrated atop a porous, bone-like metal. Advantages of the manufacturing process have led to the evaluation of porous titanium as the bone-like base material. Here, porous titanium was shown to support the growth of cartilage to produce native levels of Young's modulus, using a clinically relevant cell source. Mechanical and biochemical properties were similar or higher for the osteochondral constructs compared to chondral-only controls. Further investigation into the mechanical influence of the base on the composite material suggests that underlying pores may decrease interstitial fluid pressurization and applied strains, which may be overcome by alterations to the base structure. Future studies aim to optimize titanium-based tissue engineered osteochondral constructs to best match the structural architecture and strength of native grafts. The studies described in this manuscript follow up on previous studies from our lab pertaining to the fabrication of osteochondral grafts that consist of a bone-like poro...Continue Reading

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Citations

Jan 5, 2016·Medical Engineering & Physics·Adam B NoverClark T Hung
Feb 21, 2016·Journal of Biomechanics·Adam B NoverClark T Hung
Aug 3, 2016·Tissue Engineering. Part a·Alexander D CiganGerard A Ateshian
Oct 3, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaolei NieDong-An Wang
Feb 6, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dong WangXianlong Zhang
Feb 8, 2020·Journal of Orthopaedic Surgery and Research·Chunqiu ZhangJinduo Ye

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