Porous titanium granules promote bone healing and growth in rabbit tibia peri-implant osseous defects

Clinical Oral Implants Research
Johan Caspar WohlfahrtStaale Petter Lyngstadaas

Abstract

The aim of this study was to investigate the osteoconductive properties and biological performance of porous titanium granules used in osseous defects adjacent to titanium implants. In this animal experimental study, calibrated defects were prepared in the tibias of 24 New Zealand rabbits. The defects were randomized into two tests and one control group. The test defects were grafted with either metallic or oxidized porous titanium granules (PTG or WPTG, respectively), whereas control defects were left empty (sham). The defects were closed with a submerged coin shaped titanium implant. Defects were left for healing for 4 weeks. After healing, the implants were removed and the new bone tissue formed onto the implant surface was analyzed for run x 2, osteocalcin, collagen-I, tartrate-resistant acid phosphatase, H(+)-ATPase, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-10 gene expression using reverse transcriptase polymerase chain reaction. Wound fluid from the healed defects was analyzed for lactate dehydrogenase and alkaline phosphatase activity. Finally osteoconductivity was analyzed by micro-computed tomography and histology. Significantly more new bone formed in PTG and WPTG grafted defects compared with sham. The ...Continue Reading

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Citations

May 14, 2011·Journal of Periodontology·Johan Caspar WohlfahrtAnne Merete Aass
Feb 22, 2014·International Journal of Oral Science·Rafael Arcesio Delgado-RuizGeorgios Romanos
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