PMID: 8961872Dec 1, 1996Paper

Porphyrin abnormalities in acquired immunodeficiency syndrome

Archives of Dermatology
W J O'ConnorL Barnes

Abstract

To examine prospectively porphyrin metabolism in a human immunodeficiency virus (HIV)-positive population. Specialist referral unit at the Department of Genitourinary Medicine, St James's Hospital, Dublin, Ireland. Twenty-eight men and 5 women (age range, 18-35 years). Twenty-nine were current or previous intravenous drug abusers. Four were thought to have sexually acquired HIV infection. All had a history of acquired immunodeficiency syndrome-defining illnesses. The patients were selected as a consecutive sample from the inpatient department. Eligibility criteria were cooperation with urine and stool collection and confirmed HIV seropositivity. The patients were matched to 2 groups: 1 with normal results of porphyrin studies and the other with abnormal findings from porphyrin studies. None. Plasma, urine, and stool porphyrin excretion patterns. Of the 33 patients in the study, 13 (40%) had increased urinary porphyrin excretion. All but 2 of these patients were seropositive for hepatitis C virus. No study patient had clinical evidence of porphyria. Four patients (12%), however, had urine and stool porphyrin excretion patterns that were classic for porphyria cutanea tarda. All 4 of these patients were hepatitis C virus-positive....Continue Reading

Citations

Jul 27, 1999·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·A M FitzgeraldA M De Jaeger
Jan 8, 2013·Journal of the National Cancer Institute·Michael J SilverbergMaryam M Asgari
Apr 29, 1998·Journal of the American Academy of Dermatology·G E Gibson, M T McEvoy
Jul 20, 1999·Journal of the American Academy of Dermatology·T Y ChuangC Lewis
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J MoranR E De Salamanca
Feb 26, 2005·Plastic and Reconstructive Surgery·Katherine Au, A Mark Boustred
Aug 31, 2016·Clinical Chemistry·Nicholette M OosthuizenTahir S Pillay
Jul 2, 2015·Current Protocols in Human Genetics·Vaithamanithi-Mudumbai Sadagopa Ramanujam, Karl Elmo Anderson
Jul 26, 2015·Current HIV/AIDS Reports·Amy C Sherman, Kenneth E Sherman
Jun 26, 2001·Clinical and Experimental Dermatology·R P Sarkany
Feb 12, 1998·The British Journal of Dermatology·T MeolaN A Soter

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