Porphyrin dyads linked by a rotatable 3,3'-biphenyl scaffold: a new binding motif for small ditopic molecules

Organic & Biomolecular Chemistry
Amy R MulhollandSteven J Langford

Abstract

Synthetic access to a set of metallo- and free base bis-porphyrins has been provided by a stepwise approach involving sequential peptide and Suzuki couplings. Linking these porphyrins through a 3,3'-biphenyl bridge enables cooperative binding to ditopic ligands such as the bipyridyls. Association constants and binding stoichiometry has been determined by spectroscopic/spectrophotometric means and the differences in the binding affinities of a small series of diaza ligands is discussed in the context of structural fit and microscopic association constants.

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Citations

Aug 15, 2018·Organic & Biomolecular Chemistry·Rhys B MurphyMartin R Johnston
Aug 14, 2019·Chemistry : a European Journal·Rhys B MurphyMartin R Johnston
Jan 17, 2020·ChemPlusChem·Luka ĐorđevićDavide Bonifazi

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