Porphyrin-encapsulated metal-organic frameworks as mimetic catalysts for electrochemical DNA sensing via allosteric switch of hairpin DNA

Analytical Chemistry
Pinghua LingHuangxian Ju

Abstract

A sensitive electrochemical sensor is designed for DNA detection based on mimetic catalysis of metal-organic framework (MOF) and allosteric switch of hairpin DNA. The functional MOFs are synthesized as signal probes by a one-pot encapsulation of iron(III) meso-5,10,15,20-tetrakis(4-carboxyphenyl) porphyrin chloride (FeTCPP) into a prototypal MOF, HKUST-1(Cu), and sequentially conjugated with streptavidin (SA) as a recognition element. The resulting FeTCPP@MOF composites can mimetically catalyze the oxidation of o-phenylenediamine (o-PD) to 2,2'-diaminoazobenzene, which is a good electrochemical indicator for signal readout. The presence of target DNA introduces the allosteric switch of hairpin DNA to form SA aptamer, and thus, FeTCPP@MOF-SA probe is brought on the electrode surface via the specific recognition between SA and the corresponding aptamer, resulting in the enhancement of electrochemical signal. The "signal-on" electrochemical sensor can detect target DNA down to 0.48 fM with the linear range of 10 fM to 10 nM. Moreover, the MOF-based electrochemical sensor exhibits acceptable selectivity against even a single mismatched DNA and good feasibility in complex serum matrixes. This strategy opens up a new direction of por...Continue Reading

References

Feb 19, 1999·Science·S S ChuiI D Williams
Nov 27, 2001·Organic Letters·O Nestler, K Severin
Jun 13, 2003·Nature·Omar M YaghiJaheon Kim
Jul 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chunhai FanAlan J Heeger
Apr 29, 2004·Angewandte Chemie·Susumu KitagawaShin-ichiro Noro
Feb 3, 2005·Journal of the American Chemical Society·Nathaniel L RosiOmar M Yaghi
Mar 3, 2005·Chemical Communications : Chem Comm·Israel Goldberg
Apr 20, 2005·Accounts of Chemical Research·Kenneth S SuslickScott R Wilson
Jul 26, 2008·Nature Nanotechnology·Lizeng GaoXiyun Yan
Aug 9, 2008·Journal of the American Chemical Society·William J RieterWenbin Lin
Aug 9, 2008·Angewandte Chemie·Mircea Dincă, Jeffrey R Long
Jan 17, 2009·Journal of the American Chemical Society·Chun-Yan SunZhong-Min Su
Mar 24, 2009·Chemical Reviews·Irina BeletskayaChristine Stern
Apr 23, 2009·Chemical Society Reviews·Zhenqiang Wang, Seth M Cohen
Apr 23, 2009·Chemical Society Reviews·JeongYong LeeJoseph T Hupp
Oct 8, 2009·Journal of the American Chemical Society·Kathryn M L Taylor-PashowWenbin Lin
Jan 15, 2010·Current Opinion in Chemical Biology·Rachel C HuxfordWenbin Lin
Feb 15, 2011·Analytical Chemistry·Elaheh FarjamiElena E Ferapontova
Mar 31, 2011·Journal of the American Chemical Society·Omar K FarhaJoseph T Hupp
Jun 15, 2011·Journal of the American Chemical Society·Randy W LarsenCarissa M Vetromile
Jun 16, 2011·Journal of the American Chemical Society·Brandon J BurnettWonyoung Choe
Jul 29, 2011·Analytical Chemistry·Jing ZhengWeihong Tan
Sep 20, 2011·Angewandte Chemie·Madhab C DasBanglin Chen
Nov 11, 2011·Chemical Reviews·Lauren E KrenoJoseph T Hupp
Nov 17, 2011·Chemical Communications : Chem Comm·Arindam ModakAsim Bhaumik
Dec 24, 2011·Journal of the American Chemical Society·Zhenjie ZhangMichael J Zaworotko
Jan 3, 2012·Journal of the American Chemical Society·Zhenjie ZhangMichael J Zaworotko
May 2, 2012·Journal of the American Chemical Society·Chengfeng ZhuYong Cui
Jun 19, 2012·Journal of the American Chemical Society·Seong Jung Kwon, Allen J Bard
Jun 28, 2012·Chemical Communications : Chem Comm·Zuliang ShenHerman O Sintim
Dec 20, 2012·Chemical Communications : Chem Comm·Quanbo WangHuangxian Ju
Jun 22, 2013·Chemical Communications : Chem Comm·Xiao-Lin QiXiao-Ming Chen
Oct 16, 2013·Journal of the American Chemical Society·Dawei FengHong-Cai Zhou

❮ Previous
Next ❯

Citations

Feb 26, 2016·Critical Reviews in Analytical Chemistry·Bin YangLianming Zhang
May 11, 2017·Accounts of Chemical Research·Christian DoonanPaolo Falcaro
Jun 5, 2018·Advanced Materials·Shunzhi WangChad A Mirkin
Dec 19, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Jurong DongJianzhuang Jiang
Jun 16, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takao OhtomoYoshitaka Takagai
May 22, 2020·The Analyst·Rabbee G MahmudunnabiMuhammad J A Shiddiky
Apr 22, 2020·Chembiochem : a European Journal of Chemical Biology·Chu ShiNing Gu
Aug 14, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Abdulaziz A AlanaziRandy W Larsen
Aug 4, 2018·Analytical and Bioanalytical Chemistry·Susana CampuzanoJosé M Pingarrón
Oct 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingheng NingJianhui Wang
Jan 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linjing SuFanggui Ye
Jul 30, 2019·Critical Reviews in Analytical Chemistry·Peihong TongJianping Li
Aug 1, 2016·ChemPlusChem·Fei-Yan YiHai-Long Jiang
Sep 11, 2020·Chemical Communications : Chem Comm·Xiangheng NiuYuehe Lin
Dec 20, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qiong HuLi Niu
Jul 6, 2020·Mikrochimica Acta·Susana CampuzanoJosé M Pingarrón
Jan 29, 2020·Angewandte Chemie·Jiajie ChenStefan Kaskel
Jan 14, 2021·Materials·Catherine P Raptopoulou
Jan 29, 2021·The Analyst·Renzhong YuZhihui Dai
Mar 9, 2021·Coordination Chemistry Reviews·Xuan ZhangOmar K Farha
Apr 25, 2021·Advanced Materials·Weiqing XuChengzhou Zhu
Apr 30, 2021·Biosensors & Bioelectronics·Pedro V V RomanholoLivia F Sgobbi
Jul 31, 2019·Chemical Reviews·Pei-Long WangHong-Cai Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.