PMID: 9432522Feb 12, 1998Paper

Porphyrin sensitization and intracellular calcium changes in the prokaryote Propionibacterium acnes

Journal of Photochemistry and Photobiology. B, Biology
S RamstadA Johnsson

Abstract

Photosensitization induces intracellular free calcium changes ([Ca2+]i) in some eukaryotic cell systems which either contribute to or protect against cell inactivation. We have investigated whether or not similar changes can be induced in prokaryotes. The skin bacterium Propionibacterium acnes was sensitized using protoporphyrin IX (PP IX) or 5-aminolevulinic acid (ALA). Exogenous ALA resulted in either a preferential accumulation of protoporphyrin (ALA-PP) or of coproporphyrin and/or uroporphyrin (ALA-CP/UP) in P. acnes. For PP IX or ALA-PP sensitization, exposure to broad-band red light resulted in an increase in [Ca2+]i. For ALA-PP sensitization, this increase was transient and [Ca2+]i returned to basal levels within 5-10 min after irradiation. However, the elevated [Ca2+]i levels obtained after PP IX sensitization were maintained for at least 1 h after irradiation. In both cases, the reduction in the external calcium concentration led to an enhancement in the cell survival, indicating that induced [Ca2+]i changes may participate in photoinactivation. Sensitization by hydrophilic coproporphyrin and/or uroporphyrin (ALA-CP/UP) did not affect the [Ca2+]i levels, but higher levels of cell inactivation were obtained. It therefor...Continue Reading

References

Jul 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·J C Kennedy, R H Pottier
Jun 30, 1992·Biochimica Et Biophysica Acta·L C PenningJ Van Steveninck
Jun 1, 1992·Journal of General Microbiology·L A Onek, R J Smith
Nov 18, 1991·Biochimica Et Biophysica Acta·K G Specht, M A Rodgers
Aug 1, 1991·Photochemistry and Photobiology·E Ben-HurJ Van Steveninck
Apr 1, 1991·Molecular Microbiology·V NorrisI B Holland
Jan 1, 1991·Free Radical Biology & Medicine·G Yonuschot
Nov 1, 1990·Chemical Research in Toxicology·P NicoteraS Orrenius
May 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·Z MalikY Nitzan
Apr 27, 1987·Biochimica Et Biophysica Acta·B P Rosen
Sep 1, 1989·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·P T Castiglia
Apr 24, 1986·The New England Journal of Medicine·H Rasmussen
Jan 1, 1987·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·T B Melø
May 1, 1986·The New England Journal of Medicine·H Rasmussen
Jan 1, 1984·Archives of Dermatological Research·B KjeldstadS Sandberg
Oct 1, 1981·Photochemistry and Photobiology·S SandbergI Romslo
Jan 22, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Sandberg, I Romslo
Aug 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·F Ricchelli
Aug 1, 1995·Journal of the American Academy of Dermatology·G F Webster
Jun 1, 1994·Canadian Journal of Microbiology·C M Futsaether, A Johnsson
Dec 1, 1993·Photochemistry and Photobiology·E Ben-Her, T M Dubbelman
Jun 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Wilson, J Dobson
Aug 16, 1993·Biochemical and Biophysical Research Communications·L C PenningT M Dubbelman
Jul 1, 1996·Journal of the American Academy of Dermatology·L C LucchinaL A Drake
May 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·W DietelR Wendenburg
Jun 25, 1996·Biochemical and Biophysical Research Communications·K ArakaneM Hirobe

❮ Previous
Next ❯

Citations

Feb 19, 2003·FEMS Immunology and Medical Microbiology·Helena AshkenaziYeshayahu Nitzan
Aug 12, 1999·Journal of Photochemistry and Photobiology. B, Biology·K SzocsJ Fidy
Jan 29, 2014·Future Medicinal Chemistry·Eliana AlvesAdelaide Almeida
Aug 22, 2000·The Journal of Investigative Dermatology·W HongcharuR R Anderson
Nov 18, 2006·Lasers in Surgery and Medicine·Seung Yoon LeeMi Youn Park
Jun 15, 2013·Rapid Communications in Mass Spectrometry : RCM·Eliana AlvesAdelaide Almeida
Nov 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C A MortonL R Braathen
Jul 28, 2011·Medicinal Research Reviews·Frederick Harris, Lynne Pierpoint
Oct 24, 2008·The British Journal of Dermatology·C A MortonUNKNOWN British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group
Mar 5, 2014·Rapid Communications in Mass Spectrometry : RCM·Eliana AlvesM Rosário M Domingues
Jan 4, 2015·Cell Calcium·Delfina C DomínguezMarianna Patrauchan
Jan 6, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ståle RamstadAnders Johnsson
Nov 24, 1999·FEMS Microbiology Letters·M Imbert, R Blondeau
Nov 16, 2004·Journal of Photochemistry and Photobiology. B, Biology·Agnella D Izzo, Joseph T Walsh
Aug 3, 2017·Photodermatology, Photoimmunology & Photomedicine·Mohammad Asif SherwaniNabiha Yusuf
Jan 17, 2020·MSphere·Emma BarnardHuiying Li
May 29, 2021·Journal of Photochemistry and Photobiology. B, Biology·Seema KirarUttam C Banerjee
Aug 21, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Alexey V GulyukAlbena Ivanisevic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.