PMID: 16632751Apr 25, 2006Paper

Porphyromonas gingivalis-epithelial cell interactions in periodontitis

Journal of Dental Research
Elisoa AndrianMahmoud Rouabhia

Abstract

Emerging data on the consequences of the interactions between invasive oral bacteria and host cells have provided new insights into the pathogenesis of periodontal disease. Indeed, modulation of the mucosal epithelial barrier by pathogenic bacteria appears to be a critical step in the initiation and progression of periodontal disease. Periodontopathogens such as Porphyromonas gingivalis have developed different strategies to perturb the structural and functional integrity of the gingival epithelium. P. gingivalis adheres to, invades, and replicates within human epithelial cells. Adhesion of P. gingivalis to host cells is multimodal and involves the interaction of bacterial cell-surface adhesins with receptors expressed on the surfaces of epithelial cells. Internalization of P. gingivalis within host cells is rapid and requires both bacterial contact-dependent components and host-induced signaling pathways. P. gingivalis also subverts host responses to bacterial challenges by inactivating immune cells and molecules and by activating host processes leading to tissue destruction. The adaptive ability of these pathogens that allows them to survive within host cells and degrade periodontal tissue constituents may contribute to the i...Continue Reading

References

Dec 1, 1992·Oral Microbiology and Immunology·R J LamontG R Persson
Jun 1, 1992·The Journal of Infectious Diseases·J W St Geme, S Falkow
Dec 1, 1992·Oral Microbiology and Immunology·K WatanabeT Umemoto
Mar 15, 1991·Biochemical and Biophysical Research Communications·H T SojarR J Genco
Jan 1, 1990·Archives of Oral Biology·R J GibbonsG Davis
Dec 1, 1990·Journal of Dental Research·M HormiaI Virtanen
Feb 8, 1990·The New England Journal of Medicine·R C Williams
May 1, 1989·Journal of Dental Research·R J Gibbons
Oct 1, 1995·Infection and Immunity·R J LamontA Weinberg
Apr 14, 1995·Science·E A Clark, J S Brugge
Feb 1, 1995·Trends in Microbiology·C W CutlerC A Genco
Mar 1, 1995·Journal of Periodontal Research·M GuigandM Bonnaure-Mallet
Jan 1, 1994·Journal of Periodontal Research·J SandrosG Dahlén
Oct 1, 1993·Oral Microbiology and Immunology·A J van WinkelhoffJ de Graaff
Jul 1, 1993·Journal of Periodontal Research·L H VaahtoniemiL E Stenfors
May 1, 1993·Infection and Immunity·M J DuncanH Xie
May 1, 1993·Journal of Periodontal Research·J SandrosG Dahlén
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
Jan 1, 1996·Journal of Periodontal Research·L F Del CastilloP von den Driesch
Sep 1, 1996·Infection and Immunity·M J DuncanE C Almira
Aug 1, 1996·Journal of Periodontal Research·M WilsonB Henderson
Nov 1, 1996·Infection and Immunity·N HamadaR J Genco
Aug 1, 1996·European Journal of Oral Sciences·J SandrosP N Papapanou
Dec 1, 1996·Infection and Immunity·P FravaloM Bonnaure-Mallet
Jan 1, 1997·Infection and Immunity·A WeinbergR J Lamont
Apr 1, 1997·Current Opinion in Cell Biology·M J Robinson, M H Cobb
Jan 1, 1997·Journal of Periodontal Research·J FletcherM Wilson
May 1, 1997·Infection and Immunity·T NjorogeC A Genco

❮ Previous
Next ❯

Citations

Jul 31, 2013·Immunology and Cell Biology·Ji Eun ShinYoungnim Choi
Feb 24, 2010·Antimicrobial Agents and Chemotherapy·Vu Dang LaDaniel Grenier
Apr 18, 2012·Infection and Immunity·Toshinori KomatsuKenji Matsushita
Jul 12, 2013·BMC Microbiology·Eleonor PalmTorbjörn Bengtsson
Jun 30, 2012·BMC Complementary and Alternative Medicine·Annie MarquisDaniel Grenier
Apr 25, 2009·Journal of Leukocyte Biology·Johnah C GaliciaDenis F Kinane
Aug 5, 2008·Journal of Periodontology·Abier H SofrataAnders K Gustafsson
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Heike BoisvertMargaret J Duncan
May 31, 2014·BioMed Research International·James LiaoDaniel Grenier
Sep 6, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Muhammad IrshadMarja L Laine
Jul 6, 2014·Biointerphases·Futami Nagano-TakebeKazuhiko Endo
May 25, 2010·Acta Odontologica Scandinavica·Yunwo ZhuYuqing Hao
Oct 3, 2015·Dental Clinics of North America·John Walters, Pin-Chuang Lai
Jan 19, 2016·Experimental and Molecular Pathology·Dimitry A ChistiakovYuri V Bobryshev
Apr 18, 2014·Journal of Immunology Research·Jaroslav MysakJana Duskova
Nov 3, 2009·Periodontology 2000·Iva Stamatova, Jukka H Meurman
Jun 26, 2007·Clinical and Experimental Immunology·H E BarksbyJ J Taylor
Nov 27, 2014·Journal of Molecular Graphics & Modelling·Marni E CuenoKuniyasu Ochiai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.