Porphyromonas gingivalis induces autophagy in THP-1-derived macrophages

Molecular Oral Microbiology
M H ParkJ Chung

Abstract

Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway and is a possible mechanism in inflammatory disease. Periodontitis is an inflammatory disease caused by periodontal pathogens. Porphyromonas gingivalis, an important periodontal pathogen, activates cellular autophagy to provide a replicative niche while suppressing apoptosis in endothelial cells. However, the molecular basis for a causal relationship between P. gingivalis and autophagy is unclear. This research examines the involvement of P. gingivalis in autophagy through light chain 3 (LC3) and autophagic proteins, and the role of P. gingivalis-induced autophagy in the clearance of P. gingivalis and inflammation. To investigate the molecular mechanism of autophagy induced by P. gingivalis, PMA-differentiated THP-1-derived macrophages were infected with live P. gingivalis. The P. gingivalis increased the formation of autophagosomes in a multiplicity of infection-dependent manner, as well as autophagolysosomes. Porphyromonas gingivalis activated LC3-I/LC3-II conversion and increased the conjugation of autophagy-related 5 (ATG5) -ATG12 and the expression of Beclin1. The expressions of Beclin1, ATG5...Continue Reading

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Citations

Jan 24, 2019·Oral Diseases·Ming JiangGuangxun Zhu
Mar 15, 2020·Journal of Periodontology·Hyun Ah LeeJin Chung
Aug 11, 2020·Journal of Periodontal Research·Jeffrey L EbersoleOctavio A Gonzalez
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria GreabuEcaterina Ionescu
Nov 29, 2020·Journal of Periodontal Research·Yuhui YangWeiran Li
Dec 8, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Li MaZhengguo Cao
Nov 13, 2020·Frontiers in Cellular and Infection Microbiology·Xue YangXiaolin Tang
Jul 14, 2021·Journal of Periodontal Research·Shaowen ZhengChen Li
Aug 26, 2021·Journal of Cellular Physiology·Rui MaJun Wang

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