PMID: 8596676Oct 1, 1995Paper

Porphyromonas gingivalis outer membrane vesicles promote bacterial resistance to chlorhexidine

Oral Microbiology and Immunology
D GrenierD Mayrand

Abstract

Porphyromonas gingivalis has been frequently associated with some types of periodontal diseases and possesses various mechanisms favoring the pathogenic process. It has been recently observed that vesicles elaborated by P. gingivalis are able to protect bacteria from the bactericidal activity of human serum. The aim of the present investigation was to evaluate the ability of vesicles from P. gingivalis in protecting oral bacteria against chlorhexidine. Data indicate that vesicles released by P. gingivalis may bind chlorhexidine, thus allowing protection for itself and for other oral bacterial species. It has also been demonstrated that lipopolysaccharides are the major component involved in the binding of chlorhexidine by vesicles. The mechanism of resistance reported in this study indicates that bacterial interactions in the oral cavity may influence the sensitivity of microbes.

References

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Citations

Aug 4, 2006·Journal of Bacteriology·Sarah R Schooling, Terry J Beveridge
Dec 3, 2011·BMC Microbiology·Andrew J Manning, Meta J Kuehn
Sep 22, 2009·Critical Care : the Official Journal of the Critical Care Forum·Frank A ScannapiecoJoseph M Mylotte
Nov 11, 2008·Journal of Dentistry·Brenda P F A GomesFrancisco J Souza-Filho
Nov 7, 2015·Microbial Pathogenesis·Hong Min NgEric C Reynolds
Feb 1, 2011·Journal of Investigative and Clinical Dentistry·Henri TenenbaumChristine Roques
Apr 24, 2012·International Journal of Dental Hygiene·J CosynH De Bruyn
May 11, 2013·European Journal of Oral Sciences·Mikiyo YamaguchiShigeyuki Ebisu
Jun 27, 1998·Periodontology 2000·M Brecx
Apr 20, 2017·Traffic·Andrea Guerrero-MandujanoGraciela Castro-Escarpulli
Jul 26, 2017·Critical Reviews in Microbiology·Charlotte VolgersFrank R M Stassen
Jun 5, 2002·Journal of Endodontics·Pia Titterud SundeLeif Tronstad
Sep 2, 2018·Molecular Oral Microbiology·Susan Yost, Ana E Duran-Pinedo
Jan 16, 2007·Journal of Oral Science·Akihide TezukaYoshimitsu Abiko
Sep 8, 2016·Scientific Reports·Chih-Yun HsiaSusan Daniel
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Ye Jin, Hak-Kong Yip
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D H MeyerP M Fives-Taylor
Jun 1, 1997·Periodontology 2000·R P DarveauR C Page
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert C AlanizBrad T Cookson
Apr 11, 2019·Frontiers in Microbiology·Fabian CieplikAli Al-Ahmad
Apr 9, 2020·Frontiers in Microbiology·Julie C Caruana, Scott A Walper
May 11, 2018·Clinical and Experimental Dental Research·Evelien GeritsJan Michiels
Jan 28, 2021·International Journal of Molecular Sciences·Ella L JohnstonMaria Kaparakis-Liaskos
Aug 22, 2021·Journal of Dentistry·Zoë L S BrookesRaul Bescos

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