Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

International Journal of Cardiology
Anders HolmlundLars Lind

Abstract

To investigate if oral health parameters were impaired in patients with myocardial infarction (MI) and if there was an association with serum antibody levels against the periodontal pathogens Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa). A case-control study consisting of 100 patients with MI and 100 age- and sex-matched controls from the same geographic area was investigated regarding oral health. The MI group had significantly more periodontal bone loss (PBL), number of deepened pockets (NDP), and bleeding on probing (BOP), and lower number of teeth (NT) than the controls. After adjustment for known cardiovascular risk factors NT, BOP, and NDP still remained significantly related to MI (p=0.014, p=0.02, and p=0.0069, respectively). IgG antibody levels against Pg were higher in subjects with MI (p=0.043), as well as in those with >4 deepened pockets (p=0.05), BOP>20% (p=0.001) and PBL (p=0.0003). However, indicating a causal pathway, the relationship between MI and Pg IgG disappeared when the oral parameters were included in the logistic regression model (p=0.69). No correlation was seen between MI and Aa in the present study. Patients with MI had an impaired oral health compared to controls. Fu...Continue Reading

References

Mar 25, 1989·BMJ : British Medical Journal·K J MattilaM J Jokinen
May 1, 1989·Journal of Clinical Periodontology·C Källestål, L Matsson
Aug 1, 1982·Community Dentistry and Oral Epidemiology·A Hugoson, T Jordan
Dec 1, 1993·Community Dentistry and Oral Epidemiology·E Reich, K A Hiller
Oct 1, 1996·Journal of Periodontology·J BeckS Offenbacher
Sep 16, 1998·American Journal of Surgery·M V MendezR Garcia
Sep 16, 2000·JAMA : the Journal of the American Medical Association·P P HujoelT A DeRouen
Feb 24, 2001·Journal of the American College of Cardiology·T H HowellW G Christen
Aug 2, 2001·The Journal of the American Dental Association·P P HujoelT A Derouen
Jul 5, 2002·Journal of Dental Research·Mike Rethman
Jul 10, 2002·Periodontology 2000·Jasim M Albandar, Thomas E Rams
May 10, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Sok-Ja JanketJudith A Jones
Aug 2, 2003·Stroke; a Journal of Cerebral Circulation·Moïse DesvarieuxUNKNOWN Oral Infections and Vascular Disease Epidemiology Study (INVEST)
Aug 27, 2003·Journal of Dental Research·R TuominenA Aromaa
Jun 23, 2004·Journal of Periodontal Research·Francesco D'AiutoMaurizio S Tonetti
Jul 3, 2004·Stroke; a Journal of Cerebral Circulation·Pirkko J PussinenPaul Knekt
Jul 17, 2004·Stroke; a Journal of Cerebral Circulation·Moïse DesvarieuxThomas Kocher
Oct 1, 2004·Journal of Periodontology·Yousef S KhaderMousa A Alomari
Oct 20, 2004·Journal of Clinical Periodontology·P N PapapanouG Dahlén
Dec 3, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Jukka H MeurmanSok-Ja Janket
Dec 24, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Pirkko J PussinenPekka Jousilahti
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Steven P EngebretsonMoïse Desvarieux
Apr 29, 2005·Journal of Periodontology·Kåre BuhlinBjörn Klinge
Nov 5, 2005·Journal of Clinical Periodontology·Bruce A DyePanos N Papapanou
Dec 8, 2005·Journal of Periodontology·Poul Erik Petersen, Hiroshi Ogawa
Oct 30, 2007·Acta Odontologica Scandinavica·Tor OsterbergBertil Steen
Dec 3, 2008·International Journal of Cardiology·Andrew J S Coats

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Citations

Oct 16, 2010·Current Opinion in Nephrology and Hypertension·Monica A FisherGeorge W Taylor
Apr 9, 2010·Diabetology & Metabolic Syndrome·Roya KelishadiParinaz Poursafa
Sep 13, 2015·Journal of Clinical Periodontology·Kåre BuhlinPirkko J Pussinen
Mar 26, 2013·Journal of Clinical Periodontology·Päivi MäntyläPirkko J Pussinen
Nov 22, 2014·Journal of Periodontology·Deepika ShresthaAnwar T Merchant
Sep 2, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Makoto KanekoMitsuaki Isobe
Sep 5, 2018·European Journal of Oral Sciences·Milla PietiäinenPirkko J Pussinen
Feb 28, 2015·Journal of Periodontal & Implant Science·Carlos Martín Ardila, Isabel Cristina Guzmán
Dec 2, 2010·Journal of Periodontal Research·M BrageA Johansson
Jan 12, 2020·Current Topics in Medicinal Chemistry·Abhishek WadhawanTeodor T Postolache
Aug 15, 2020·Contemporary Clinical Dentistry·Elena Nikolaevna NikolaevaSergey Darchoevich Arutyunov
Apr 5, 2021·International Journal of Cardiology·Elisabetta Cotti, Giuseppe Mercuro
Sep 22, 2021·Journal of Clinical Periodontology·Chaitanya JoshiKarolin Hijazi
Oct 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Yusra ZaidiKristine Y DeLeon-Pennell

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