Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism

Frontiers in Microbiology
Jia-Shun WuXin-Hua Liang

Abstract

Microbiota has been widely considered to play a critical role in human carcinogenesis. Human papilloma virus, hepatitis B and C virus, and Helicobacter pylori are implicated in the pathogenesis of cancer of uterine cervix, liver, and stomach, respectively. However, whether Porphyromonas gingivalis (P. gingivalis), a common Gram negative oral bacteria, is associated with oral carcinogenesis still remains unclear and its underlying mechanism needs to be addressed. Here, we established a combined experimental system of 4NQO-induced oral carcinoma model and chronic periodontitis model and investigated the effects of P. gingivalis infection on oral carcinogenesis and fatty acid metabolism during oral carcinogenesis. The data showed that in this animal model, P. gingivalis infection induced mice periodontitis, increased the tongue lesion size and multiplicity of each mouse and promoted oral cancer development. P. gingivalis treatment significantly increased the level of free fatty acids and altered the fatty acid profile in tongue tissues and the serum of mice. And P. gingivalis induced the formation of fatty liver of the mice. Besides, immunohistochemical analysis and qRT-PCR showed that the expression of fatty-acid synthase and ace...Continue Reading

References

Dec 1, 1996·Oral Microbiology and Immunology·K HiroseI Ueda
Jun 26, 1999·The Journal of Biological Chemistry·M FebbraioR L Silverstein
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·J V SwinnenG Verhoeven
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 24, 1956·Science·O WARBURG
Sep 23, 2003·Infection and Immunity·Ashish JainThomas E Van Dyke
Jan 4, 2005·Journal of Lipid Research·Sin H GiengFrancisco J Rosales
Jul 12, 2005·Oncogene·Daniel E BauerCraig B Thompson
Oct 18, 2005·Cancer Cell·Georgia HatzivassiliouCraig B Thompson
Mar 21, 2006·Biochemical Society Transactions·R W BrownseyW M Lee
May 19, 2006·Cancer Research·Véronique ChajèsVirginie Joulin
Sep 2, 2006·Journal of Periodontology·Marcelo FaveriLuciene Cristina de Figueiredo
May 23, 2007·Archives of Otolaryngology--head & Neck Surgery·Mine TezalFrank A Scannapieco
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S WarnakulasuriyaE Dabelsteen
Feb 19, 2008·Microbes and Infection·Masae KuboniwaOzlem Yilmaz
Nov 27, 2008·Journal of Lipid Research·Ira J GoldbergNada A Abumrad
Dec 3, 2008·Journal of Lipid Research·Salih J Wakil, Lutfi A Abu-Elheiga
Mar 26, 2009·Journal of the National Cancer Institute·Toshiro MigitaMassimo Loda
Nov 10, 2009·Journal of Dentistry·Sarah G Fitzpatrick, Joseph Katz
Dec 31, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lei-Ya FangYuh-Ling Chen
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 15, 2011·Carcinogenesis·Mathias T Rosenfeldt, Kevin M Ryan
Oct 21, 2011·International Journal of Oral Science·Joseph KatzSeunghee Cha
Jun 25, 2013·Cell Metabolism·Erin CurrieRobert V Farese
Jul 12, 2013·Carcinogenesis·Dominique S Michaud
Feb 28, 2014·Nature·Seth B Coffelt, Karin E de Visser
Apr 11, 2014·Journal of the National Cancer Institute·Sabina SieriVittorio Krogh
Oct 30, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M AskariA Pirzadeh

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Citations

Sep 19, 2019·Journal of Periodontal Research·Irene Lafuente Ibáñez de MendozaJosé Manuel Aguirre Urizar
Feb 25, 2020·Journal of Dental Research·Z R FitzsimondsR J Lamont
May 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiyu LiuLei Cheng
Aug 20, 2020·Journal of Dental Research·F R F TelesY Wang
Oct 27, 2020·Cancer Immunology, Immunotherapy : CII·Xin PangYa-Ling Tang
Nov 18, 2020·Cellular Oncology (Dordrecht)·Miao-Fen ChenWen-Cheng Chen
Jan 15, 2021·Scientific Reports·Divya GopinathNewell W Johnson
Jan 22, 2021·Critical Reviews in Microbiology·Paola ZanettaBarbara Azzimonti
May 11, 2021·Frontiers in Oncology·Natarajan BhaskaranPushpa Pandiyan
Jun 17, 2021·Oncology Reports·Xiaoxiao LiXingdong Chen

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Methods Mentioned

BETA
PCR
X-ray

Software Mentioned

GraphPad Prism
Statistical Package for Social Science

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