Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver disease

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Gary A AbramsRonald H Clements

Abstract

Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that can lead to hepatic fibrosis and cirrhosis. Portal fibrosis in the absence of NASH, called isolated portal fibrosis (IPF), has received less attention and has not been classified as a spectrum of NAFLD. The aims of this study were to determine the prevalence of IPF in subjects undergoing gastric bypass surgery, to identify biochemical variables associated with IPF, and to assess the metabolic syndrome as defined by the AdultTreatment Panel III criteria. We analyzed liver biopsies from 195 morbidly obese subjects after excluding all other causes of liver disease. The prevalence of fatty liver (FL) only, IPF, and NASH was 30.3%, 33.3%, and 36.4%, respectively. Several biochemical parameters significantly trended across the 3 groups, with IPF falling between FL and NASH. Hyperglycemia was the only metabolic parameter associated with NASH (OR, 5.4; 95% CI, 2.4-12; P < .0001) and IPF (OR, 2.8; 95% CI, 1.2-6.5; P = .01). Subjects with diabetes had the greatest risk for NASH (OR, 8; 95% CI, 3.3-19.7; P < .0001) and IPF (OR, 4.3; 95% CI, 1.6-11.6; P = .003). The metabolic syndrome was identified in 78.5% of subjects, and a signifi...Continue Reading

References

May 1, 1977·Archives of Internal Medicine·J M CampbellP H Forsham
Jan 1, 1983·Scandinavian Journal of Gastroenterology·P SchlichtingH Poulsen
Jun 1, 1996·Gastrointestinal Endoscopy·J PoniachikE R Schiff
Apr 16, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F H LuyckxP J Lefèbvre
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C P Day, O F James
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
May 14, 1999·The Journal of Clinical Endocrinology and Metabolism·P MarceauJ G Kral
Sep 14, 1999·The American Journal of Gastroenterology·E M BruntB R Bacon
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Jun 2, 2000·Gastroenterology·V RatziuT Poynard
Feb 17, 2001·Gastroenterology·E C MunJ B Matthews
Mar 15, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M C AlessiI Juhan-Vague
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 9, 2001·The Surgical Clinics of North America·P R Schauer, S Ikramuddin
Oct 30, 2001·The Proceedings of the Nutrition Society·S W Coppack
Dec 18, 2001·Experimental Biology and Medicine·F M Gregoire
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Oct 3, 2002·The American Journal of Gastroenterology·Jean P MollestonJoseph F Fitzgerald
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Oct 31, 2002·Gastroenterology·Arun J Sanyal, UNKNOWN American Gastroenterological Association
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Ali H MokdadJames S Marks
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Oct 15, 2003·Archives of Internal Medicine·Roland Sturm
Aug 1, 1952·A.M.A. Archives of Internal Medicine·S ZELMAN

❮ Previous
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Citations

Jul 1, 2005·Digestive Diseases and Sciences·P SorrentinoP Conca
Jul 5, 2007·Obesity Surgery·Xiuli LiuGary A Abrams
Jan 25, 2008·Obesity Surgery·Kamran QureshiGary A Abrams
Jan 26, 2008·Obesity Surgery·Hsien-Liang HuangKuo-Chin Huang
Mar 23, 2013·Hepatology International·Monika Ciupińska-KajorLukasz Liszka
Jul 28, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S FrancqueL Van Gaal
Dec 19, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M MancoV Nobili
Apr 9, 2005·Current Opinion in Gastroenterology·Jay H Lefkowitch
Mar 22, 2006·Current Opinion in Gastroenterology·Jay H Lefkowitch
Jun 17, 2006·Minerva cardioangiologica·G Marchesini, M Babini
Dec 12, 2012·Annals of Surgery·Sweta TandraRaj Vuppalanchi
Oct 15, 2011·Immunotherapy·Jeff J SubleskiRobert H Wiltrout
Jun 5, 2014·International Journal of Molecular Sciences·Kira BettermannJohannes Haybaeck
Oct 12, 2010·Expert Review of Gastroenterology & Hepatology·Leon A Adams, Ariel E Feldstein
Jul 25, 2012·Clinics in Liver Disease·Evelyn Hsu, Karen Murray
Aug 23, 2011·The Medical Clinics of North America·Remco FranssenJohn J P Kastelein
Nov 9, 2010·Clinics in Liver Disease·Kathryn Law, Elizabeth M Brunt
Apr 24, 2010·Human Pathology·Fréderic CharlotteUNKNOWN LIDO Study Group
Oct 13, 2009·Clinics in Liver Disease·Elizabeth M Brunt
Oct 13, 2009·Clinics in Liver Disease·Mangesh PagadalaArthur J McCullough
Oct 6, 2009·Gastroentérologie Clinique Et Biologique·P Angulo
Oct 24, 2007·American Journal of Clinical Pathology·Matthew M Yeh, Elizabeth M Brunt
Sep 9, 2008·Endocrinology and Metabolism Clinics of North America·Remco FranssenJohn J P Kastelein
Jun 5, 2007·Clinics in Liver Disease·Eve A Roberts
Jun 5, 2007·Clinics in Liver Disease·Leon A Adams, Paul Angulo
Mar 28, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Steven H BelleUNKNOWN Longitudinal Assessment of Bariatric Surgery Consortium Writing Group
Apr 21, 2007·Journal of Hepatology·Eve A Roberts
Feb 27, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Luca MieleAntonio Grieco
Dec 27, 2005·Clinics in Liver Disease·Diana R Mager, Eve A Roberts
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean Pappas Molleston
Jul 23, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sachin S KundeGary A Abrams
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey B SchwimmerJoel E Lavine
Oct 27, 2006·Histopathology·S G Hübscher
Apr 25, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guilherme M CamposRaphael B Merriman

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