Portal hemodynamic effects of lenvatinib in patients with advanced hepatocellular carcinoma: a prospective cohort study

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Hisashi HidakaWasaburo Koizumi

Abstract

Lenvatinib is an oral multitargeted tyrosine kinase inhibitor which suppress tumor angiogenesis and tumor progression. It was non-inferior to sorafenib in overall survival in untreated advanced hepatocellular carcinoma (HCC). Sorafenib had a beneficial effect on portocollateral circulation with portal hypertension in translating and clinical studies. However, the hemodynamic effects of lenvatinib appear to be different from those of sorafenib because the efficacy of lenvatinib for VEGFRs and FGFRs is different from that of sorafenib. This study was prospectively performed to evaluate the portal hemodynamic effect of lenvatinib in patients with advanced HCC using duplex Doppler ultrasonography (DDU). Twenty-eight Child-Pugh class-A or B patients with advanced HCC received lenvatinib depending on body weight daily for 2 weeks. Primary outcomes were changes in the hemodynamics of the portal venous system by using DDU before and after the 2-week administration of lenvatinib. The portal venous flow velocity (PVV; cm/second) significantly reduced (27 ± 12.1 vs. 22.6 ± 8.0, P = 0.019), while portal venous area (PVA; cm2 ) did not change after the 2-week administration (0.80 ± 0.36 vs. 0.82 ± 0.27, P = 0.665). Therefore, the congestion...Continue Reading

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Citations

Jan 10, 2021·Pharmaceuticals·Takeshi HatanakaSatoru Kakizaki
May 30, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Manon AllaireDominique Thabut

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