Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?

Canadian Journal of Gastroenterology & Hepatology
David KaraIyad Kabar

Abstract

Portal hypertension is a serious complication of liver cirrhosis. To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension. This was a retrospective study of liver transplant candidates who underwent upper gastrointestinal endoscopy between April 2011 and November 2015. A total of 1,045 upper endoscopies were analyzed. Portal hypertensive gastric and duodenal polyps were frequently observed and were associated with thrombocytopenia (p = 0.040; OR: 2.4, 95% CI 1.04-5.50), Child-Pugh score > 6 (p = 0.033; OR: 2.3, 95% CI 1.07-4.92), Model for End Stage Liver Disease score > 16 (p = 0.030; OR: 4.1, 95% CI 1.14-15.00), and previous rubber band ligation (p < 0.001; OR = 5.2, 95% CI 2.5-10.7). These polyps often recurred after polypectomy; however, no malignant transformation occurred during the observational time until October 2017. The most common endoscopic finding was esophageal varices, observed in more than 90% of patients. Portal hypertensive polyposis is common in patients with advanced cirrhosis. Our data suggest that these polyps have benign characteristics.

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Citations

Mar 19, 2020·Gastroenterology Research and Practice·Firdevs TopalFatih Esad Topal
Mar 22, 2021·Gastrointestinal Endoscopy Clinics of North America·Alexander Ross RobertsonMarco Pennazio
Jun 19, 2021·Clinics and Research in Hepatology and Gastroenterology·Vincent Zimmer, Kai Emrich
Jul 3, 2021·International Journal of Molecular Sciences·Helge Waldum, Reidar Fossmark
Nov 27, 2019·Gastrointestinal Tumors·Waseem M Seleem, Amr Shaaban Hanafy

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS® Statistics

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