Portal insulin delivery is superior to peripheral delivery in handling of portally delivered glucose

Metabolism: Clinical and Experimental
M KubotaT Kamada

Abstract

It is still controversial as to whether physiological portal insulin delivery has metabolic advantages over peripheral insulin delivery. To clarify this issue, glycemic regulation during intravenous (IVGTT) and oral (OGTT) glucose tolerance tests and hyperglycemic clamp studies with either peripheral or portal glucose infusion was investigated in left-segmentally pancreatectomized dogs with portal ([PPx] n = 7) or systemic ([Tx] n = 7) venous drainage of the remaining pancreas. In Tx dogs, systemic diversion of pancreatic venous effluent was accomplished by gastroduodenal-caval shunt. Data obtained were compared with those in normal control dogs ([NC] n = 7). The loss of pancreatic beta-cell mass in PPx dogs decreased insulin responses to peripheral and portal glucose loads. In contrast, Tx dogs showed insulin responses comparable to those of NC dogs to glucose loads via both routes. Against peripheral glucose loads (IVGTT and hyperglycemic clamp with peripheral glucose infusion), PPx and Tx dogs showed deteriorated glucose handling. Against portal glucose loads (OGTT and hyperglycemic clamp with portal glucose infusion), deteriorated glucose handling was observed in Tx dogs, but not in PPx dogs. Deterioration in glycemic regul...Continue Reading

References

Aug 1, 1981·Metabolism: Clinical and Experimental·R W StevensonK G Alberti

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Citations

May 10, 2008·Archives of Physiology and Biochemistry·Francesco FrascaRiccardo Vigneri
Apr 9, 2016·Advanced Drug Delivery Reviews·Hélène MalhaireFrédéric Lagarce

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