PMID: 8592423Jan 1, 1996Paper

Portal vein branch occlusion induces cell proliferation of cholestatic rat liver

The Journal of Surgical Research
S MizunoS Yoshida

Abstract

Portal vein branch occlusion induces atrophy of occluded hepatic lobes, concomitantly associated with the complementary hypertrophy of unoccluded lobes. In this context, selective embolization of the portal vein branch supplying the area to be resected has been performed prior to extended hepatectomy to reduce the risk of postoperative liver failure. However, carcinoma of the hepatic hilus is often associated with obstructive jaundice. At present it is still obscure whether cholestatic hepatocytes can also respond well to the proliferation stimuli caused by the portal vein branch embolization. To clarify this point, we made a rat model of portal vein branch ligation in combination with cholestasis. As an indicator of proliferation, we determined the activity of DNA polymerase alpha and the mitotic index. The results demonstrate that, even in the cholestatic liver, the expression of DNA polymerase alpha in unoccluded lobes was induced by contralateral portal vein branch ligation. The maximal degree of DNA polymerase alpha induction in the cholestatic liver was similar to that in the noncholestatic liver, i.e., fivefold above that in the resting liver. The level of DNA polymerase alpha activity correlated well with the mitotic in...Continue Reading

Citations

Jun 1, 2008·Seminars in Interventional Radiology·Robin D KimKevin E Behrns
Sep 6, 2011·Annual Review of Physiology·Natasha C Lucki, Marion B Sewer
Sep 21, 2000·Journal of Vascular and Interventional Radiology : JVIR·M NaginoY Nimura
Jun 11, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Y NaganoH Shimada
Feb 28, 2003·Surgical Oncology Clinics of North America·Dalliah M Black, Kevin E Behrns
May 8, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ahmer HameedLawrence Yuen
Jul 16, 2014·The Journal of Surgical Research·Floor HuismanThomas M van Gulik
Mar 27, 2001·The Journal of Surgical Research·T KyokaneY Nimura
Mar 30, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Christian PicardYves Horsmans
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KaidoM Imamura
Mar 27, 2007·Journal of Hepato-biliary-pancreatic Surgery·Yukihiro YokoyamaYuji Nimura
Oct 3, 2007·Journal of Hepato-biliary-pancreatic Surgery·Yukihiro YokoyamaYuji Nimura
Aug 24, 1999·The Journal of Surgical Research·M UrayamaM Tsukamoto
Jun 22, 2002·Journal of Hepatology·Yasuhiko NaganoHiroshi Shimada

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