Portal vein thrombosis and liver cirrhosis: Long-term anticoagulation is effective and safe

Clinics and Research in Hepatology and Gastroenterology
Michel BergèreJérôme Dumortier

Abstract

Portal vein thrombosis (PVT) is a common complication of liver cirrhosis. Anticoagulation therapy is efficient, but is associated with potentially severe side-effects, especially bleeding episodes. It is therefore still unclear which patients will benefit from anticoagulation, and for what duration. The aim of the present study was to retrospectively analyse our single centre experience on long-term anticoagulation in patients presenting a PVT, complicating cirrhosis. Data of 40 cirrhotic patients with PVT treated by anticoagulation therapy from June 2003 to May 2018 were collected. Regular imaging was performed to monitor the outcome of PVT. The hemorrhagic complications and the recurrence of the PVT after anticoagulation withdrawal were also analyzed. The median follow-up under anticoagulation therapy was 33.7 months. Complete (57.5%) or partial (25.0%) recanalization of PVT was observed. Fifteen bleeding episodes (37.5%) occurred in our population, related to portal hypertension in 7 (46.7%). Eleven (73.3%) patients required hospitalization and eight (53.3%) required blood transfusion. No patient died from bleeding complication. Anticoagulation was stopped in 10 patients (25.0%), because of regression of PVT in 5 patients or...Continue Reading

References

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Citations

Feb 23, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Dominique C Valla
Aug 21, 2020·Seminars in Thrombosis and Hemostasis·Oana Nicoară-FarcăuJuan Carlos García-Pagán
Oct 9, 2020·Clinical Transplantation·Josephine BertXavier Verhelst
May 1, 2021·Journal of Hepatology·Marco SenzoloJuan Carlos García-Pagán

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