Portal vein thrombosis in liver cirrhosis: incidence, management, and outcome

BMC Gastroenterology
Shunichiro FujiyamaHiromitsu Kumada

Abstract

Portal vein thrombosis (PVT) is a serious complication in liver cirrhosis with portal hypertension. We examined the treatment, recurrence and prognosis of PVT in cirrhotic patients. The study subjects were all 90 cirrhotic patients with PVT treated with danaparoid sodium (DS) at our department between July 2007 and September 2016. The mean age was 68 years and mean Child-Pugh score was 7. All patients received 2500 U/day of DS for 2 weeks, and repeated in those who developed PVT recurrence after the initial therapy. Complete response was noted in 49% (n = 44), partial response (shrinkage ≥70%) in 33% (n = 30), and no change (shrinkage <70%) in 18% (n = 16) of the patients after the initial course of treatment. DS treatment neither caused adverse events, particularly bleeding or thrombocytopenia, nor induced significant changes in serum albumin, total bilirubin, prothrombin time, and residual liver function. Re-treatment was required in 44 patients who showed PVT recurrence and 61% of these responded to the treatment. The cumulative recurrence rates at 1 and 2 posttreatment years were 26 and 30%, respectively. The recurrence rates were significantly lower in patients with acute type, compared to the chronic type (p = 0.0141). Th...Continue Reading

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Citations

Mar 8, 2019·Current Opinion in Gastroenterology·Roula Sasso, Don C Rockey
Feb 13, 2018·Current Opinion in Organ Transplantation·Fanny TuronJuan Carlos García-Pagán
Jul 12, 2019·Journal of Clinical and Translational Hepatology·Matthew WuMicheal Tadros
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Dec 24, 2018·Clinics and Research in Hepatology and Gastroenterology·Michel BergèreJérôme Dumortier
Oct 2, 2021·Clinical and Translational Gastroenterology·Shixue XuXingshun Qi

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