Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
I I RaadD P Kontoyiannis

Abstract

Conventional amphotericin B-based antifungal therapy for invasive fusariosis in patients with a hematologic malignancy results in a > or = 70% failure rate. Posaconazole is a broad-spectrum antifungal agent with in vitro and in vivo activity against Fusarium species. In this retrospective analysis of patients from 3 open-label clinical trials, we evaluated posaconazole for the treatment of invasive fusariosis. Twenty-one patients with proven or probable invasive fusariosis who had disease refractory to or who were intolerant of standard antifungal therapy received oral posaconazole suspension (800 mg per day in divided doses) as salvage therapy. Successful outcome occurred in 10 (48%) of all 21 patients. Among patients with leukemia who received posaconazole therapy for >3 days, the overall success rate was 50%; for patients who recovered from myelosuppression, the success rate was 67%, compared with 20% for those with persistent neutropenia. These results suggest that posaconazole is useful for the treatment of invasive fusariosis.

References

Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T J WalshE J Anaissie
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·M Lozano-ChiuJ H Rex
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T J Walsh, A H Groll
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Jun 27, 2002·The British Journal of Ophthalmology·R RahmanM E Taylor
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectElizabeth Johnson
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio NucciElias Anaissie
Apr 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R Perfect

❮ Previous
Next ❯

Citations

Oct 13, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Simone Cesaro, Piero Marson
Aug 13, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Guarro
Oct 27, 2006·Current Infectious Disease Reports·Arlo Upton, Kieren A Marr
Oct 24, 2008·Current Infectious Disease Reports·Patricia MuñozEmilio Bouza
Sep 4, 2012·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Idil YenicesuZeynep Arzu Yeğin
Mar 31, 2007·Nature Reviews. Drug Discovery·Carol A KauffmanPeter Kirkpatrick
Jan 26, 2007·The New England Journal of Medicine·Oliver A CornelyDavid Angulo-Gonzalez
Jan 26, 2007·The New England Journal of Medicine·Andrew J UllmannSimon Durrant
May 19, 2007·Medical Mycology·Fernanda P Silveira, Shahid Husain
May 19, 2007·Medical Mycology·Joshua PerlrothBrad Spellberg
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vijayalakshmi Nagappan, Stan Deresinski
Apr 7, 2007·Current Opinion in Pulmonary Medicine·Alejandro Sanchez, Robert Larsen
Feb 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeannina A Smith, Carol A Kauffman
Apr 30, 2008·Antimicrobial Agents and Chemotherapy·Anna Maria TortoranoMaria Anna Viviani
Jul 14, 2010·Antimicrobial Agents and Chemotherapy·Olivier LortholaryUNKNOWN French Mycoses Study Group
May 13, 2009·Antimicrobial Agents and Chemotherapy·Elizabeth S Dodds AshleyEddie Power
Jan 13, 2010·Antimicrobial Agents and Chemotherapy·Nathan P WiederholdThomas F Patterson
Feb 4, 2009·Antimicrobial Agents and Chemotherapy·Mery Ruíz-CendoyaJosep Guarro
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Mónica AzorJosep Guarro
Oct 16, 2007·Clinical Microbiology Reviews·Marcio Nucci, Elias Anaissie
Jan 29, 2011·Journal of Clinical Microbiology·Prithviraj BoseRonald A Greenfield
Dec 30, 2011·Journal of Clinical Microbiology·Anna Maria TortoranoGiuliana Lo Cascio
Jan 5, 2011·American Journal of Respiratory and Critical Care Medicine·Andrew H LimperUNKNOWN American Thoracic Society Fungal Working Group
May 14, 2010·Proceedings of the American Thoracic Society·Clifford Quan, Brad Spellberg
Aug 14, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Ralf KrügerKarl J Lackner
Jan 1, 2010·Drug, Healthcare and Patient Safety·Dionissios NeofytosAnna-Pelagia Magiorakos
Aug 29, 2007·Drugs·Anurag N Malani, Carol A Kauffman
May 21, 2010·Clinical Pharmacokinetics·Yanjun LiHartmut Derendorf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Thomas J WalshJohn R Perfect
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Marcio NucciElias J Anaissie
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
I I RaadAndrew J Ullmann
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
John R PerfectElizabeth Johnson
© 2022 Meta ULC. All rights reserved