Posaconazole for the treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.

The Journal of Antimicrobial Chemotherapy
J PeriselnerisD Armstrong-James

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) can accelerate lung function decline in patients with cystic fibrosis (CF). Antifungal medication can be used in addition to systemic corticosteroid treatment. We evaluated Aspergillus-specific IgE and the use of therapeutic drug monitoring of triazoles in a retrospective analysis of 32 patients. There was a significant reduction in Aspergillus IgE with posaconazole but not with other triazoles (P = 0.026). Aspergillus IgE levels were inversely correlated with the therapeutic drug level of posaconazole. These data suggest that posaconazole is better than comparator azoles at decreasing serological response to Aspergillus and that this response was better with therapeutic levels of posaconazole.

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Citations

Sep 11, 2019·Current Opinion in Pulmonary Medicine·Renske van der MeerHarry G M Heijerman
Nov 20, 2019·Antimicrobial Agents and Chemotherapy·Emily E RosowskiAnna Huttenlocher
Apr 24, 2020·Drugs·Lu ChenRoger J M Brüggemann
May 7, 2020·Current Opinion in Pediatrics·Archana Chacko, Richard B Moss
Jan 5, 2021·Current Opinion in Pulmonary Medicine·Valliappan MuthuRitesh Agarwal
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Hélène GueganJean-Pierre Gangneux
Apr 4, 2021·Antibiotics·Aidan K Curran, David L Hava
Jun 4, 2021·The Annals of Pharmacotherapy·Madeline G Tompkins, Rebecca Pettit
Apr 5, 2021·Mycopathologia·Amelia BercussonAnand Shah
Dec 20, 2021·Therapeutic Drug Monitoring·Benjamin KablyEliane M Billaud

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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