Position effect of cross-strand side-chain interactions on beta-hairpin formation

Protein Science : a Publication of the Protein Society
Clara M SantiveriM Angeles Jiménez

Abstract

Previous conformational analysis of 10-residue linear peptides enabled us to identify some cross-strand side-chain interactions that stabilize beta-hairpin conformations. The stabilizing influence of these interactions appeared to be greatly reduced when the interaction was located at the N- and C-termini of these 10-residue peptides. To investigate the effect of the position relative to the turn of favorable interactions on beta-hairpin formation, we have designed two 15-residue beta-hairpin forming peptides with the same residue composition and differing only in the location of two residues within the strand region. The conformational properties of these two peptides in aqueous solution were studied by 1H and 13C NMR. Differences in the conformational behavior of the two designed 15-residue peptides suggest that the influence of stabilizing factors for beta-hairpin formation, in particular, cross-strand side-chain interactions, depends on their proximity to the turn. Residues adjacent to the turn are most efficient in that concern. This result agrees with the proposal that the turn region acts as the driving force in beta-hairpin folding.

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Citations

Apr 24, 2010·Journal of Medicinal Chemistry·Concepción SolanasCarlos Cativiela
Jan 10, 2009·Journal of Medicinal Chemistry·Concepción SolanasCarlos Cativiela
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