Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13

Cancer Genetics and Cytogenetics
Matthew J FerberAntoinette A T P Brink

Abstract

Molecular cytogenetic analysis frequently shows human papillomavirus (HPV) integration near translocation breakpoints in cervical cancer cells. We have recently described a cluster of HPV18 integrations in the distal end of the common fragile site FRA8C at 8q24 in primary cervical carcinoma samples. Chromosome band 8q24 contains the MYC gene (alias c-MYC), FRA8C, and FRA8D. The MYC gene is frequently deregulated--usually by translocation or amplification--in various tumor types. In the present study, we performed a molecular cytogenetic analysis of HPV18 integration patterns and the 8q24 translocation in a primary cervical carcinoma and in HeLa cells using combined binary ratio-fluorescence in situ hybridization. Our aim was to determine how the chromosomal breaks involved in these events relate physically to the MYC gene; whether they map to the FRA8C site, the FRA8D site, or both; and how they correlate with the occurrence of DNA flexibility domains. The 8q24 translocation breakpoints mapped between stretches of integrated HPV18 sequences in the distal end of FRA8C. This region contained DNA helix flexibility clusters, several of which mapped in the vicinity of HPV integration sites and translocation breakpoints in cervical c...Continue Reading

References

Jan 1, 1991·Advances in Cancer Research·C A Spencer, M Groudine
Sep 19, 1989·Biochemistry·A SaraiR L Jernigan
Jan 11, 1995·Nucleic Acids Research·J MautnerA Polack
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Jeon, P F Lambert
Jun 1, 1997·Cancer Genetics and Cytogenetics·U EgeliN Ozyardímcí
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·D MishmarB Kerem
Mar 3, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·G CeçenerA Kizil
Mar 3, 1999·American Journal of Human Genetics·D MishmarB Kerem
Jul 14, 1999·Nature·P K MagnussonU B Gyllensten
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Jun 27, 2000·Cancer Genetics and Cytogenetics·B TuncaA Kizil
Oct 31, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L Hecht, J C Aster
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·P K MagnussonU B Gyllensten
Apr 3, 2001·International Journal of Cancer. Journal International Du Cancer·F LuftM von Knebel Doeberitz
Jul 17, 2001·Journal of Cellular Biochemistry. Supplement·E Y SvetlovaM Debatisse
Mar 15, 2003·Cancer Letters·Nicholas C Popescu

❮ Previous
Next ❯

Citations

Jul 28, 2006·Journal of Assisted Reproduction and Genetics·Andrew A HennebergPhilip J Chan
Oct 31, 2012·International Journal of Molecular Sciences·Ke MaZheng Li
Jan 12, 2011·Annual Review of Immunology·Monica GostissaRoberto Chiarle
Sep 23, 2014·Cellular and Molecular Life Sciences : CMLS·Alexandros G GeorgakilasVassilis G Gorgoulis
Oct 11, 2014·Cellular and Molecular Life Sciences : CMLS·Ge Gao, David I Smith
Nov 28, 2006·Seminars in Cancer Biology·Jane BayaniJeremy A Squire
Jul 11, 2008·Genes, Chromosomes & Cancer·Ryan L RaglandThomas W Glover
Jan 9, 2010·Clinical and Experimental Dermatology·G NakanishiK Iwatsuki
Jun 30, 2006·DNA Repair·Martin F ArltThomas W Glover
Apr 14, 2005·Seminars in Cancer Biology·Pierre Aman
Apr 18, 2015·BioMed Research International·Teresa ColomboPaola Paci
Dec 23, 2014·Oncogene·M A WadeJ M Allan
Feb 2, 2008·Toxicology·Fitz B Collings, Vishal S Vaidya
Aug 28, 2007·Journal of Cellular Biochemistry·Patrizia GaspariniMarco A Pierotti
Nov 9, 2007·Leukemia·B SchneiderR A F MacLeod
Dec 23, 2006·Nature Reviews. Cancer·Ciaran B J WoodmanLawrence S Young
May 15, 2015·The Open Medical Informatics Journal·Aditi DagaValentina Umrania
Jun 4, 2019·Journal of Clinical Pathology·Jayashree AdhikaryAmlan Ghosh
Jul 5, 2007·Annual Review of Genetics·Sandra G Durkin, Thomas W Glover

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Molecular and Cellular Biology
Eitan ZlotorynskiBatsheva Kerem
Proceedings of the National Academy of Sciences of the United States of America
D MishmarBatsheva Kerem
International Journal of Hematology
Hideshi Ishii, Yusuke Furukawa
Cancer Letters
Thomas W Glover
© 2021 Meta ULC. All rights reserved