Positive Alpha-defensin at Reimplantation of a Two-stage Revision Arthroplasty Is Not Associated with Infection at 1 Year

Clinical Orthopaedics and Related Research
Linsen T SamuelCarlos A Higuera

Abstract

Diagnosing periprosthetic joint infection (PJI) represents a challenge that relies on multiple clinical and laboratory criteria that may not be consistently present. The synovial alpha-defensin-1 (AD-1) test has been shown to correlate accurately with the Musculoskeletal Infection Society (MSIS) criteria for the diagnosis of PJI, however, its association with persistent PJI has not been elucidated in the setting of patients receiving antibiotic spacers during second-stage reimplantation. Applying a Delphi-based consensus to define successful eradication of PJI offers an opportunity to test the utility of AD-1 in this setting. (1) Can the AD-1 test determine whether infection has been controlled using the Delphi criteria for persistent PJI as a surrogate for infection eradication during two-stage revision for PJI treatment with a spacer? (2) How does the performance of the AD-1 test compare with the MSIS criteria? This was a multicenter analysis of retrospectively collected data on patients who underwent a two-stage revision arthroplasty between May 2014 and July 2016. We included patients who had a previously confirmed PJI and received a cement spacer, underwent the second stage, had MSIS criteria data and a synovial fluid AD-1...Continue Reading

References

Aug 30, 2000·The Journal of Bone and Joint Surgery. British Volume·F S HaddadI Bacarese-Hamilton
Dec 7, 2005·Clinical Orthopaedics and Related Research·Matthew J KraayMichael J Salata
Mar 20, 2010·Clinical Orthopaedics and Related Research·Mark F KurdJavad Parvizi
Aug 26, 2011·Clinical Orthopaedics and Related Research·S M Javad MortazaviJavad Parvizi
Sep 23, 2011·Clinical Orthopaedics and Related Research·Javad ParviziCharalampos G Zalavras
Dec 15, 2012·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Mohit BhandariJon E Block
Feb 27, 2013·Clinical Orthopaedics and Related Research·Claudio Diaz-LedezmaJavad Parvizi
Apr 17, 2013·The Journal of Arthroplasty·Benjamin ZmistowskiJavad Parvizi
Mar 5, 2014·Clinical Orthopaedics and Related Research·Carl DeirmengianJavad Parvizi
Jun 20, 2014·Clinical Orthopaedics and Related Research·Carl DeirmengianJavad Parvizi
Sep 5, 2014·The Journal of Bone and Joint Surgery. American Volume·Carl DeirmengianJavad Parvizi
Sep 27, 2014·Clinical Orthopaedics and Related Research·Joshua BinghamBrynn Goldberg
Jan 30, 2015·Clinical Orthopaedics and Related Research·Carl DeirmengianRobert E Booth
Feb 13, 2016·Clinical Orthopaedics and Related Research·Alisina ShahiCarl Deirmengian
Jun 28, 2016·Clinical Orthopaedics and Related Research·Tommaso BonanzingaThorsten Gehrke
Sep 6, 2017·The Journal of Bone and Joint Surgery. American Volume·Alisina ShahiJavad Parvizi

❮ Previous
Next ❯

Citations

Feb 12, 2020·Surgical Infections·Ellis BernsDioscaris R Garcia
Jul 15, 2020·Expert Review of Molecular Diagnostics·Eric SennevilleHenri Migaud
Mar 3, 2021·The Journal of Arthroplasty·Christopher N CarenderNicholas A Bedard
Jan 3, 2021·The Journal of Arthroplasty·Lindsay T Kleeman-ForsthuberJason M Jennings
Jun 5, 2021·Clinical Orthopaedics and Related Research·Charalampos G Zalavras, Carlos Higuera-Rueda
Nov 2, 2021·SICOT-J·Tejbir S PannuCarlos A Higuera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.