Positive and negative roles of the trans-acting T cell factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Béatrice Kunz, W Held

Abstract

Members of the Ly-49 gene family code for class I MHC-specific receptors that regulate NK cell function. Due to a combinatorial distribution of Ly-49 receptors, NK cells display considerable clonal heterogeneity. The acquisition of one Ly-49 receptor, Ly-49A is strictly dependent on the transcriptional trans-acting factor T cell-specific factor-1 (TCF-1). Indeed, TCF-1 binds to two sites in the Ly-49a promoter and regulates its activity, suggesting that the Ly-49a gene is a direct TCF-1 target. TCF-1 deficiency resulted in the altered usage of additional Ly-49 receptors. We show in this study, using TCF-1 beta(2)-microglobulin double-deficient mice, that these repertoire alterations are not due to Ly-49/MHC class I interactions. Our findings rather suggest a TCF-1-dependent, cell autonomous effect on the acquisition of multiple Ly-49 receptors. Besides reduced receptor usage (Ly-49A and D), we also observed no effect (Ly-49C) and significantly expanded (Ly-49G and I) receptor usage in the absence of TCF-1. These effects did not in all cases correlate with the presence of TCF binding sites in the respective proximal promoter. Therefore, besides TCF-1 binding to the proximal promoter, Ly-49 acquisition may also be regulated by TC...Continue Reading

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Citations

Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vassilios IoannidisWerner Held
Mar 23, 2004·Annual Review of Immunology·Wayne M YokoyamaAnthony R French
Jun 6, 2006·Nature Immunology·Anouk CarauxClaude Roth
Apr 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Claude RothGreg Lemke
Dec 3, 2010·PLoS Genetics·Kristi KerkelBenjamin Tycko
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arefeh RouhiDixie L Mager
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Andrew StewartJohn Trowsdale
Sep 7, 2006·European Journal of Immunology·Grégoire JeannetWerner Held
Nov 30, 2011·The Journal of Experimental Medicine·Natalie A BezmanLewis L Lanier
Apr 16, 2021·The Journal of Experimental Medicine·Zhong-Yin LiBarbara L Kee
Nov 30, 2002·Seminars in Immunology·Rebecca H Lian, Vinay Kumar

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