Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population

Disease Markers
Yevhen I DubovykAlexander V Ataman

Abstract

There are a lot of convincing evidences about the involvement of endothelin pathway proteins in the pathogenesis of atherosclerosis and its fatal complications. In this study, the analysis of a possible association between EDN1 rs5370 and EDNRA rs5335 gene polymorphisms and the risk of large artery stroke (LAS) in a Ukrainian population was conducted. 200 LAS patients and 200 unrelated controls were enrolled in a case-control study. The polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP) was used for SNP genotyping. Our results revealed that EDN1 rs5370 polymorphism was associated with LAS development both before and after adjustment for atherosclerosis risk factors (sex, age, body mass index, arterial hypertension, type 2 diabetes mellitus, and smoking). The risk for a LAS incident in rs5370-T allele carriers was 1.6 times higher (CI = 1.066-2.403; P = 0.020) than in subjects with the GG genotype. No link between EDNRA rs5335 and LAS risk in a Ukrainian population was found. The present study indicated that EDN1 rs5370, but not EDNRA rs5335, can be the strong genetic predictor for LAS development in a Ukrainian population.

References

Jan 4, 2003·Hypertension·Jing Ji JinTetsuro Miki
Jun 17, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chihiro TanakaToshiyuki Miyata
Jul 9, 2005·Stroke; a Journal of Cerebral Circulation·Kelly GormleyHugh S Markus
Jul 10, 2007·Cardiovascular Research·Felix Böhm, John Pernow
Dec 20, 2007·Journal of Cardiovascular Pharmacology·Marc Iglarz, Martine Clozel
Aug 8, 2009·Stroke; a Journal of Cerebral Circulation·Leah R MacClellanSteven J Kittner
Aug 13, 2009·Journal of Atherosclerosis and Thrombosis·María PalacínEliecer Coto
Sep 17, 2011·Human Mutation·Francesco PivaGiovanni Principato
Mar 1, 2012·British Journal of Pharmacology·W KittikulsuthD M Pollock
Jan 24, 2014·PLoS Computational Biology·Jaroslav BendlJiri Damborsky
Mar 19, 2014·Cell Biochemistry and Biophysics·Lei Zhang, Rubo Sui
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Jan 1, 2014·Global Cardiology Science & Practice·R Jay Widmer, Amir Lerman
Aug 8, 2015·American Journal of Respiratory and Critical Care Medicine·Raymond L BenzaHemant K Tiwari
Apr 24, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wanwan MaZhen Zhang

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Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

FATHMM
PredictSNP2
SpliceAid2
PredictSNP
SNPinfo
PolyPhen2
Statistical Package for Social Science software ( SPSS

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