Positive Association of Plasma Homocysteine Levels with Cardio-Ankle Vascular Index in a Prospective Study of Japanese Men from the General Population

Journal of Atherosclerosis and Thrombosis
Eva Mariane MantjoroToshiro Takezaki

Abstract

Observational studies have reported that elevated homocysteine (Hcy) levels are associated with the risk of cardiovascular disease (CVD). However, interventions that lower Hcy do not provide a corresponding risk reduction. Therefore, the causal role of Hcy in CVD remains unclear. This 5-year prospective study investigated the associations of Hcy levels, folate intake, and host factors with arterial stiffness among the general Japanese population. We prospectively recruited 658 participants (40-69 years old) from the general population during regular health checkup examinations. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) at baseline and the 5-year follow-up. Folate intake was estimated using a structured questionnaire. Genotyping was used to evaluate the MTHFR C677T and MS A2756G gene polymorphisms. Ultrafast liquid chromatography was used to measure total plasma Hcy levels. Association between these variables and CAVI values was evaluated using general linear regression and logistic regression models that were adjusted for atherosclerosis-related factors. Men had higher Hcy levels and CAVI values and lower folate intake than women (all, p<0.001). At baseline, Hcy, folate intake, and the two ge...Continue Reading

References

Sep 1, 1975·Atherosclerosis·K S McCully, R B Wilson
Aug 19, 1992·JAMA : the Journal of the American Medical Association·M J StampferC H Hennekens
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·P VerhoefM J Stampfer
Aug 1, 1995·International Journal of Epidemiology·E ArnesenJ E Nordrehaug
Mar 24, 1998·Annual Review of Medicine·H RefsumS E Vollset
May 20, 1998·European Journal of Pediatrics·R G MatthewsC Goulding
Nov 26, 2002·BMJ : British Medical Journal·David S WaldJoan K Morris
Dec 21, 2005·International Journal of Cardiology·Angelika de BreePilar Galan
May 31, 2006·Journal of Atherosclerosis and Thrombosis·Kohji ShiraiMasanobu Takata
Aug 31, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jun TayamaTakayoshi Toyota
Sep 2, 2006·Stroke; a Journal of Cerebral Circulation·Shinichi SatoTakashi Shimamoto
Dec 14, 2006·JAMA : the Journal of the American Medical Association·Lydia A BazzanoJiang He
Feb 5, 2008·Diabetes Research and Clinical Practice·Junko IbataKishio Nanjo
Jun 28, 2008·Annals of Clinical Biochemistry·Stuart J Moat
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalGeorgia Salanti
Nov 23, 2011·Journal of Atherosclerosis and Thrombosis·Kazuyo HirasadaToshiro Takezaki
Mar 6, 2013·Journal of Atherosclerosis and Thrombosis·Vladimir SoskaTomas Freiberger
Apr 3, 2013·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Jinpeng ZhongHui Chen
Aug 31, 2013·Annual Review of Pathology·Suping Zhang, Thomas J Kipps
Oct 25, 2014·Journal of Atherosclerosis and Thrombosis·Petr DobsakKohji Shirai
Apr 22, 2015·The Journal of Clinical Hypertension·Xiao-Na WangHong-Mei Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Jun SuzukiKohji Shirai
© 2022 Meta ULC. All rights reserved