Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease

The American Journal of the Medical Sciences
César A Paz-Y-MiñoPaola E Leone

Abstract

Alzheimer's disease (AD) is the most common cause of senile dementia. In Ecuador, the number of deaths caused by AD increases each year. Epidemiologically, the Ecuadorian population is composed of a mixture of several genetic backgrounds along with environmental factors, that make it unique and ideal for population studies. The main objective of this study was to determine the prevalence of Cystatin C (CST3), Cathepsin D (CTSD) and Manganese superoxide dismutase (MnSOD) amino acid-altering polymorphisms and their influence on the development of AD in the Ecuadorian population. This is a case-control study consisting of 56 patients with AD, from the Department of Neurology at Carlos Andrade Marín Hospital. The control group (n = 55) comprised healthy elderly adults. The inclusion period was from January to August of 2012. Peripheral blood was collected from both groups for DNA extraction, polymerase chain reaction and capillary sequencing. There was a positive association between a CTSD polymorphism (Ala224Val) and the development of AD (odds ratio = 8.1, 95% confidence interval: 0.9-85.7; P < 0.025). However, the 3 other polymorphisms investigated did not show significant associations with AD. Variations in CTSD and MnSOD showe...Continue Reading

References

Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I TouitouH Rochefort
Aug 21, 2003·Progress in Neurobiology·Paul R TurnerWickliffe C Abraham
Sep 11, 2009·Indian Journal of Psychiatry·E MohandasB Raghunath
Jul 6, 2010·Acta Neurologica Scandinavica·B-H JeongY-S Kim
Aug 10, 2013·Lancet·Clement T LoyJohn B J Kwok

❮ Previous
Next ❯

Citations

Oct 1, 2016·Investigación Y Educación En Enfermería·Irma Yolanda Castillo AvilaLuis Reinaldo Alvis Estrada
May 19, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Martin RegensburgerJürgen Winkler
Feb 15, 2018·Frontiers in Aging Neuroscience·Md Sahab UddinAdrian M Stankiewicz
Nov 25, 2016·Frontiers in Molecular Neuroscience·Wanda M Snow, Benedict C Albensi
Sep 24, 2020·Journal of Neurochemistry·Melina OverhoffNatalia L Kononenko
Nov 17, 2020·Frontiers in Aging Neuroscience·Yaling JiangLu Shen
Oct 12, 2021·Frontiers in Neuroscience·Luca MuzioGianvito Martino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.