Positive clinical outcome with IVIg as monotherapy in recurrent pemphigoid gestationis

International Immunopharmacology
Tegan NguyenA Razzaque Ahmed

Abstract

Pemphigoid gestationis (PG) is an autoimmune blistering disease associated with pregnancy. It is characterized by the presence of autoantibodies against bullous pemphigoid antigens in the basement membrane zone. A 32 year old female developed PG in the first pregnancy and had a stillbirth. PG recurred during the second trimester of her second pregnancy. Systemic corticosteroid therapy was cause for concern since patient developed gestational diabetes. Patient was unwilling to use insulin. Intravenous immunoglobulin (IVIg) was used as a treatment of last resort. The dose was 2g/kg/cycle. It was given every two weeks antepartum and every three weeks for three months postpartum. PG improved within four weeks of IVIg therapy. Serum and tissue immunopathological studies were negative prior to delivery. A healthy neonate was born. No adverse events to IVIg were observed. No disease was observed ten months postpartum.

References

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Citations

Feb 18, 2016·International Journal of Inflammation·Lyubomir A DourmishevLjubka G Miteva
Jun 17, 2016·Acta neurologica Belgica·Ameneh Zare-ShahabadiSeyed Mohammad Baghbanian
Feb 3, 2018·American Journal of Clinical Dermatology·Carolyn J KushnerVictoria P Werth
Aug 4, 2018·Frontiers in Immunology·A Razzaque Ahmed, Srinivas Kaveri
Sep 22, 2018·Drugs·Kyle T AmberMichael Hertl
Dec 18, 2020·Frontiers in Medicine·Giovanni GenoveseAngelo Valerio Marzano

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