Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON).

Journal of Magnetic Resonance Imaging : JMRI
Grigorios KorosoglouMatthias Stuber

Abstract

To investigate the utility of inversion recovery with ON-resonant water suppression (IRON) to create positive signal in normal lymph nodes after injection of superparamagnetic nanoparticles. Experiments were conducted on six rabbits, which received a single bolus injection of 80 mumol Fe/kg monocrystalline iron oxide nanoparticle (MION-47). Magnetic resonance imaging (MRI) was performed at baseline, 1 day, and 3 days after MION-47 injection using conventional T(1)- and T(2)*-weighted sequences and IRON. Contrast-to-noise ratios (CNR) were measured in blood and in paraaortic lymph nodes. On T(2)*-weighted images, as expected, signal attenuation was observed in areas of paraaortic lymph nodes after MION-47 injection. However, using IRON the paraaortic lymph nodes exhibited very high contrast enhancement, which remained 3 days after injection. CNR with IRON was 2.2 +/- 0.8 at baseline, increased markedly 1 day after injection (23.5 +/- 5.4, P < 0.01 vs. baseline), and remained high after 3 days (21.8 +/- 5.7, *P < 0.01 vs. baseline). CNR was also high in blood 1 day after injection (42.7 +/- 7.2 vs. 1.8 +/- 0.7 at baseline, P < 0.01) but approached baseline after 3 days (1.9 +/- 1.4, P = NS vs. baseline). IRON in conjunction with ...Continue Reading

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Citations

Apr 29, 2009·Journal of Neurotrauma·Laura E Gonzalez-LaraPaula J Foster
Oct 17, 2009·European Heart Journal·Christian M MatterMatthias Nahrendorf
Nov 5, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Patrick M WinterSamuel A Wickline
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mehran M SadeghiLynne L Johnson
May 21, 2010·Future Medicinal Chemistry·Dipanjan PanGregory M Lanza
Sep 17, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jason S WeinsteinEdward A Neuwelt
Apr 13, 2015·Journal of Magnetic Resonance·S DelangreY Gossuin
Jun 10, 2010·Investigative Radiology·Nils A KrämerGabriele A Krombach

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