PMID: 8608408Oct 1, 1995Paper

Positive correlation between cellular glutathione and acquired cisplatin resistance in human ovarian cancer cells

Cell Biology and Toxicology
G ChenW J Zeller

Abstract

While multiple changes are frequently found to be associated with cisplatin resistance in a variety of tumor cell lines, a cause-effect relationship of these alterations with the resistant phenotype has not been established. In order to identify the resistance-relevant determinants, a series of cisplatin-resistant sublines with different degrees of resistance to cisplatin was developed in a human ovarian carcinoma cell line (O-129). Three derived resistant cell lines displayed 2.1-fold (O-129/DDP4, low), 4.1-fold (O-129/DDP8, moderate) and 6.3-fold (O-129/DDP16, high) resistance, respectively, to cisplatin, compared with the sensitive parental line O-129. While the activity of poly(ADP-ribose) polymerase, an enzyme proposed to be involved in DNA repair, was elevated in all three resistant lines, a significant karyotypic change was observed only in the high-resistance line with the karyotype alteration from near diploidy to heteroploidy. The moderate (4.1-fold) and high (6.3-fold) DDP resistance was associated with a slow proliferation rate in drug-free medium, but cellular glutathione level was highly correlated with DDP sensitivity in all four cell lines. Taken together, the present studies establish that while many changes at...Continue Reading

References

Jan 1, 1979·Methods in Enzymology·R G Worton, C Duff
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A K GodwinM E Anderson
Aug 1, 1992·British Journal of Cancer·H Timmer-BosschaE G de Vries
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·G Chen, W J Zeller
Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·G A HospersE G de Vries
Jan 1, 1988·Cancer Chemotherapy and Pharmacology·A de GraeffS Rodenhuis
Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L Dexter, J T Leith
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·G Chen, W J Zeller
Mar 12, 1993·International Journal of Cancer. Journal International Du Cancer·M G ChabertP Mandel

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Citations

Jun 7, 2002·Critical Reviews in Oncology/hematology·Bernard Desoize, Claudie Madoulet
Jun 23, 2000·Drugs·G Giaccone
Mar 29, 2014·European Journal of Medicinal Chemistry·Olga NovakovaViktor Brabec
May 16, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Tereza MuchovaViktor Brabec
Nov 6, 2014·Experimental and Therapeutic Medicine·Fugen WangZhaobin Cai
Aug 29, 1998·The Journal of Biological Chemistry·Q LiE Reed
May 20, 2020·Nature Communications·Eva P S EiblKristin S Vogfjörd
Jul 4, 2013·Human & Experimental Toxicology·J M SerpeloniL M G Antunes
Feb 12, 2017·The Biochemical Journal·Yasemin Sunucu KarafakıoğluA Fatih Fıdan

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