PMID: 3763050Aug 29, 1986Paper

Positive correlation between contamination by blood and amino acid levels in cerebrospinal fluid of the rat

Neuroscience Letters
M E KornhuberG M Hartmann

Abstract

The degree of contamination by blood in macroscopically clear cerebrospinal fluid (CSF) from the rat was assessed by the red blood cell count. Amino acid concentrations in the same samples were determined using high performance liquid chromatography. A significant positive correlation between the number of erythrocytes and amino acid concentration was found for alanine, asparagine, aspartate, citrulline, glutamate, glycine, phenylalanine and taurine but not for glutamine, histidine, isoleucine, leucine, lysine, methionine, ornithine, serine, threonine, tyrosine and valine. The difference in amino acid concentration between samples that were or were not contaminated by blood was as much as one order of magnitude for aspartate, glutamate, glycine and taurine; the concentrations of these amino acids were highly correlated with the erythrocyte counts (r = 0.87, P = 0.000002 for glutamate). The results suggest that macroscopical inspection is often not sufficient to judge contamination by blood in the CSF.

References

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Citations

Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·D B MastersB R Komisaruk
Apr 1, 1990·Psychiatry Research·K E McFarlinN S Nadi
Jan 1, 1996·Brain Research Bulletin·Y L HuangH A Hansson
Apr 20, 2000·Hearing Research·L ZhengW Kong
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robin A de GraafKevin L Behar
Dec 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·V G SchweitzerE Peterson
Nov 16, 2019·Fluids and Barriers of the CNS·Marta BatlloriRafael Artuch
Jun 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B T WoodsonE L Peterson

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