Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.

Cancer Research
Jonna FrasorAdina Stanculescu

Abstract

Estrogen receptors (ER) and nuclear factor-kappaB (NF-kappaB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we have recently found that ER and NF-kappaB can also act together in a positive manner to synergistically increase gene transcription. To examine the extent of cross-talk between ER and NF-kappaB, a microarray study was conducted in which MCF-7 breast cancer cells were treated with 17beta-estradiol (E(2)), tumor necrosis factor alpha (TNFalpha), or both. Follow-up studies with an ER antagonist and NF-kappaB inhibitors show that cross-talk between E(2) and TNFalpha is mediated by these two factors. We find that although transrepression between ER and NF-kappaB does occur, positive cross-talk is more prominent with three gene-specific patterns of regulation: (a) TNFalpha enhances E(2) action on approximately 30% of E(2)-upregulated genes; (b) E(2) enhances TNFalpha activity on approximately 15% of TNFalpha-upregulated genes; and (c) E(2) + TNFalpha causes a more than additive upregulation of approximately 60 genes. Consistent with their prosurvival roles, ER and NF-kappaB and their target gene, BIRC3, are involved in protecting breast ...Continue Reading

References

Sep 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T KuukasjärviJ Isola
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z L ChuD W Ballard
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J AnD C Leitman
Mar 27, 2001·Molecular Endocrinology·S WissinkP T van der Saag
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·D K BiswasA B Pardee
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Oct 27, 2001·Circulation Research·M J EvansD C Harnish
Sep 10, 2002·The Journal of Biological Chemistry·Christina R ArntScott H Kaufmann
Sep 19, 2002·The Journal of Biological Chemistry·Christina Tzagarakis-FosterDale C Leitman
Oct 25, 2003·Oncogene·Robert ClarkeLeena A Hilakivi-Clarke
Mar 24, 2004·Trends in Endocrinology and Metabolism : TEM·Christian J GruberJohannes C Huber
Mar 24, 2004·The Journal of Biological Chemistry·Yuka ToyoshimaDerek LeRoith
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L A deGraffenriedG R Weiss
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Debajit K BiswasJ Dirk Iglehart
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Yamei ZhouChristopher C Benz
Mar 31, 2005·Molecular and Cellular Biology·Serena GhislettiElisabetta Vegeto
Aug 23, 2005·Endocrine-related Cancer·Y ZhouC C Benz
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lance D MillerJonas Bergh
Sep 13, 2005·Molecular Cancer·Lingegowda S MangalaKapil Mehta
Feb 18, 2006·Molecular Cell·Aleksandra CvoroDale C Leitman
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruxana T SadikotTimothy S Blackwell
Apr 13, 2006·The Journal of Biological Chemistry·Fabio StossiBenita S Katzenellenbogen
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xiao-Jun MaMark G Erlander
Jan 11, 2007·Breast Cancer Research and Treatment·Maria Aparecida NagaiFernando A Soares
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurice P H M JansenEls M J J Berns
Mar 21, 2007·Nature Cell Biology·Xiaobo WangGail E Sonenshein
Oct 13, 2007·Molecular Endocrinology·Kendall W NettlesGeoffrey L Greene
Apr 29, 2008·Current Opinion in Genetics & Development·Willscott E Naugler, Michael Karin

❮ Previous
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Citations

Oct 19, 2013·Bulletin of Experimental Biology and Medicine·A M ScherbakovN E Kushlinskii
Jun 28, 2011·Breast Cancer Research and Treatment·Maral JamshidiHeli Nevanlinna
Feb 9, 2011·Medical Oncology·Hong LinJinxiang Cheng
Nov 17, 2010·Cell Research·Deborah Veis Novack
Mar 5, 2013·Bioinformatics·George WuHongkai Ji
Oct 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erik J TokarMichael P Waalkes
Jul 11, 2012·Cell Communication and Signaling : CCS·Mihaela MarinaSusan E Conrad
Sep 12, 2012·Breast Cancer Research : BCR·Leen SasSteven J Van Laere
Dec 29, 2015·Cancer Letters·Cecilia WilliamsJan-Åke Gustafsson
Feb 26, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Jennifer R Ribeiro, Richard N Freiman
Dec 10, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Govindarajah Vinothini, Siddavaram Nagini
Mar 28, 2017·Cellular Signalling·Angeles C Tecalco-CruzLeticia Rocha-Zavaleta
Jan 19, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anil Kumar AgrawalSiddarth Agrawal
Oct 20, 2018·Journal of Cellular and Molecular Medicine·Yingxiang HouTing Zhuang
Dec 23, 2015·Molecular Endocrinology·Anne V McNamaraMichael R H White
Apr 13, 2019·Endocrine-related Cancer·Emmanuelle FleurotJérôme Levallet
Sep 8, 2012·Current Allergy and Asthma Reports·Adeel Zubair, Marianne Frieri

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