Positive effect of alendronate on subchondral bone healing and subsequent cartilage repair in a rabbit osteochondral defect model

The American Journal of Sports Medicine
Kohei NishitaniTakashi Nakamura

Abstract

Cartilage and subchondral bone have recently been considered an osteochondral unit. The treatment of osteochondral lesions is still challenging, but better subchondral bone repair may result in higher quality repaired cartilage. Alendronate accelerates bone formation in osteochondral defects and affects the quality of the repaired cartilage. Controlled laboratory study. Osteochondral defects were made on the left trochleas of 50 rabbits, which were assigned to 1 of 3 groups: control, ALN (weekly subcutaneous injection of 0.14 mg/mL alendronate), and ALN-S (alendronate injection in the first 8 weeks only). They were evaluated at 4, 8, 24, and 52 weeks. Bone repair was evaluated with microcomputed tomography and histologic evaluation. Cartilage repair was evaluated with ultrasound and histologic analyses. At 4 weeks, the defects were filled, and cartilage-like repair tissue was observed in the ALN group, whereas the defects were incompletely filled in the control group. Alendronate treatment enhanced early bone formation and mineralization in the osteochondral defect for the first 8 weeks. The continuous injection of alendronate for 24 weeks resulted in delayed bone remodeling, but the rabbits in the ALN-S group showed good integ...Continue Reading

References

Jun 24, 1972·Lancet·E R RadinR M Rose
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Jan 1, 1993·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Y MatsusueH Hama
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C P PeterG A Rodan
Feb 24, 2001·The Journal of Bone and Joint Surgery. American Volume·D W JacksonT M Simon
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C LiH Norimatsu
Oct 18, 2001·Clinical Orthopaedics and Related Research·J R SteadmanJ J Rodrigo
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yongping CaoHiromichi Norimatsu
Jan 12, 2005·Arthritis Research & Therapy·Koji HattoriYoshinori Takakura
Mar 9, 2006·International Orthopaedics·Cengiz SenNurper Onuk Filiz
Aug 4, 2006·Biochemical and Biophysical Research Communications·E J DombrechtL S De Clerck
Jun 15, 2007·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Hiroshi KurokiTakashi Nakamura
Oct 18, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carol MuehlemanKoichi Masuda
Nov 13, 2008·Journal of Cellular Biochemistry·Isabel R OrrissTimothy R Arnett
Nov 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Louis C GerstenfeldThomas A Einhorn
Feb 21, 2009·The Journal of Bone and Joint Surgery. American Volume·Timothy M Wright, Suzanne A Maher

❮ Previous
Next ❯

Citations

Oct 12, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Baoding HuangCody Bünger
Dec 22, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomasz L NosewiczHanna Schell
Feb 12, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jacques MenetreyIwan Van Breuseghem
May 18, 2016·Journal of Clinical Orthopaedics and Trauma·Nevres Hürriyet AydoğanKadir Bahadır Alemdaroğlu
Apr 5, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takaaki ShiraiTakashi Nakamura
Dec 16, 2009·The American Journal of Sports Medicine·Allen F Anderson, Margaret Smith
Jul 28, 2017·Tissue Engineering. Part C, Methods·Christian G PfeiferRobert L Mauck

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.