Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials

Frontiers in Cellular and Infection Microbiology
Ruixue Huang, Jianan Hu

Abstract

Context: Constipation in children is a prevalent, burdensome, and psychologically important pediatric issue, the treatment of which remains a global challenge. The use of probiotics has been reported for management of the gastrointestinal microbiota.Objective:This study reviewed the existing literatures of 6 Randomized Control Trials (RCTs) to ascertain some baseline understanding and available information for the effects of probiotics on stool frequency and consistency in children with constipation.Data Sources:PubMed, Springer, Elsevier Science, Cochrane Library, Scopus, Ovid (Medline, EMBASE, PsycINFO), Orbis, and Web of Science from the earliest record in each database to 15 September, 2016.Study selection:Eligible studies were randomized controlled trials that compared the effect of probiotics interventions to any control intervention on stool frequency and consistency.Data Extraction:Studies were identified by searching electronic databases. The meta-analysis was performed by Review Manager 5.3 software using a randomized model.Results:Six studies were identified. The use of probiotics significantly increased the stool frequency [mean difference (MD), 0.73; 95% confidence interval (CI), 0.14-1.31;P= 0.02]. Subgroup assess...Continue Reading

References

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Citations

Nov 30, 2019·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Daiane Oliveira Vale San Gomes, Mauro Batista de Morais
Feb 27, 2020·Expert Review of Gastroenterology & Hepatology·Bridget R Southwell
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Feb 2, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Chengcheng ZhangWei Chen
Jul 3, 2021·Nutrients·Leontien Depoorter, Yvan Vandenplas

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Software Mentioned

RevMan
Cochrane
Ovid

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