Positive effects of fampridine on cognition, fatigue and depression in patients with multiple sclerosis over 2 years

Journal of Neurology
Sarah D BroicherMichael Linnebank

Abstract

To assess the effects of PR-fampridine on cognitive functioning, fatigue and depression in patients with multiple sclerosis (PwMS). Thirty-two PwMS were included in this trial. Cognitive performance was assessed in an open-label and randomized double-blind, placebo-controlled study design using a comprehensive neuropsychological test battery as well as questionnaires examining depression and fatigue. We found significant improvements in cognitive measures assessing alertness (tonic alertness, p = 0.0244 and phasic alertness, p = 0.0428), psychomotor speed (p = 0.0140) as well as verbal fluency (p = 0.0002) during open-label treatment with PR-fampridine. These effects of performance were paralleled by patients' perception of reduced fatigue (physical, p = 0.0131; cognitive, p = 0.0225; total, p = 0.0126). Fampridine-induced improvements in phasic alertness (p = 0.0010) and measures of fatigue (physical, p = 0.0014; cognitive, p = 0.0003; total, p = 0.0005) were confirmed during randomized, double-blind, placebo-controlled assessment in the second year. In addition, we found positive effects of PR-fampridine on depressive symptoms (p = 0.0049). We demonstrated persisting beneficial effects of PR-fampridine on fatigue in PwMS over...Continue Reading

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Citations

Mar 5, 2019·Expert Review of Neurotherapeutics·Maria Pia AmatoAngelo Bellinvia
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Mar 4, 2021·Neurology. Neuroimmunology and Neuroinflammation·Michael DietrichPhilipp Albrecht
Apr 15, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Maria A RoccaMassimo Filippi

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