PMID: 8614642Apr 1, 1996Paper

Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation

Nucleic Acids Research
H S ChangS L Phillips

Abstract

Transcription of the murine laminin gamma 1 gene is activated during retinoic acid/cAMP induced differentiation of F9 embryonal carcinoma cells. Positive transcription control elements associated with two DNase I hypersensitive regions in the large first intron of the gene have been identified which confer a differentiation response on the laminin gamma 1 promoter. However, the kinetics of transcriptional activation suggest each DNA region interacts with transcription factors appearing at different times during differentiation. Synergy between the two regions in cis causes high level activation.

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Citations

Aug 31, 2001·Journal of Cellular Biochemistry·Y Chen, J M Keller
Oct 31, 2000·Microscopy Research and Technique·P TunggalM C Ott
Dec 2, 1999·The Journal of General Virology·S Urcuqui-InchimaF Bernardi

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