Positive emotions and brain reward circuits in chronic pain

The Journal of Comparative Neurology
Edita NavratilovaFrank Porreca

Abstract

Chronic pain is an important public health problem that negatively impacts the quality of life of affected individuals and exacts enormous socioeconomic costs. Chronic pain is often accompanied by comorbid emotional disorders including anxiety, depression, and possibly anhedonia. The neural circuits underlying the intersection of pain and pleasure are not well understood. We summarize recent human and animal investigations and demonstrate that aversive aspects of pain are encoded in brain regions overlapping with areas processing reward and motivation. We highlight findings revealing anatomical and functional alterations of reward/motivation circuits in chronic pain. Finally, we review supporting evidence for the concept that pain relief is rewarding and activates brain reward/motivation circuits. Adaptations in brain reward circuits may be fundamental to the pathology of chronic pain. Knowledge of brain reward processing in the context of pain could lead to the development of new therapeutics for the treatment of emotional aspects of pain and comorbid conditions.

References

Sep 24, 1999·Pain·Howard L Fields
Jun 12, 2003·Trends in Neurosciences·A D Craig
Feb 21, 2004·Science·Tor D WagerJonathan D Cohen
Mar 9, 2004·Nature Neuroscience·Joshua P Johansen, Howard L Fields
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Vania ApkarianDarren R Gitelman
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Feb 28, 2006·Current Pain and Headache Reports·Misha-Miroslav BackonjaCharles Argoff
May 16, 2006·Lancet·Henrik KehletClifford J Woolf
Oct 7, 2006·The Journal of Pain : Official Journal of the American Pain Society·Patrick B WoodDavid L Lilien
Jun 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tor D WagerJon-Kar Zubieta
Jul 6, 2007·The European Journal of Neuroscience·Patrick B WoodBoris A Chizh
Nov 22, 2007·Clinical Pharmacology and Therapeutics·B G OertelJ Lötsch
Jan 30, 2008·European Journal of Pain : EJP·Lino Becerra, David Borsook
Mar 21, 2008·Nature Reviews. Neuroscience·Siri Leknes, Irene Tracey
Jul 8, 2008·The Journal of Pain : Official Journal of the American Pain Society·Adley TsangMakoto Watanabe
Jul 17, 2008·Current Psychiatry Reports·Oye Gureje
Aug 2, 2008·The European Journal of Neuroscience·Siri LeknesIrene Tracey
Aug 15, 2008·Consciousness and Cognition·D A DentonG F Egan
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chantal Villemure, M Catherine Bushnell
Apr 3, 2009·Annals of the New York Academy of Sciences·Jon-Kar Zubieta, Christian S Stohler
Sep 29, 2009·Nature Neuroscience·Tamara KingFrank Porreca
Aug 14, 2010·Pain·Nanna Brix FinnerupTroels Staehelin Jensen
Apr 15, 2011·PloS One·Siri LeknesIrene Tracey
Jun 28, 2011·Nature Methods·Tal YarkoniTor D Wager
Mar 24, 2012·Neuroscience Letters·Susanne BeckerPetra Schweinhardt
May 15, 2012·Neuroscience Letters·Melissa A FarmerA Vania Apkarian
Jul 4, 2012·Nature Neuroscience·Marwan N BalikiA Vania Apkarian
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Edita NavratilovaFrank Porreca
Mar 19, 2013·Annals of the New York Academy of Sciences·Edita NavratilovaFrank Porreca
Mar 19, 2013·Progress in Neurobiology·David BorsookJon Levine
Apr 12, 2013·The New England Journal of Medicine·Tor D WagerEthan Kross
May 21, 2013·Annals of Neurology·Milena De FeliceFrank Porreca
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jul 6, 2013·Progress in Neurobiology·Igor ElmanNora D Volkow
Aug 29, 2013·Brain : a Journal of Neurology·Javeria A HashmiA Vania Apkarian
Sep 3, 2013·Neuroscience Letters·Garth T WhitesideJeffrey D Kennedy
Jan 23, 2014·Arthritis & Rheumatology·Marco L LoggiaVitaly Napadow

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Citations

Jun 28, 2016·Brain : a Journal of Neurology·Irene Tracey
Aug 4, 2016·Anatomical Science International·Katsuya KamiEmiko Senba
Nov 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Junying WangGerhard Litscher
Feb 22, 2017·Journal of Evaluation in Clinical Practice·Matthew Low
Jun 10, 2017·Nature Reviews. Drug Discovery·Ajay S YekkiralaClifford J Woolf
May 4, 2018·Pain Practice : the Official Journal of World Institute of Pain·Lydia Wai TaiChi Wai Cheung
Sep 21, 2017·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Ajay ManhapraJane C Ballantyne
Apr 2, 2019·Scientific Reports·Natália KocselGabriella Juhász
Mar 23, 2019·Pharmacological Reviews·S Stevens Negus
Feb 1, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Felipe Araya-QuintanillaCelia Álvarez-Bueno
Nov 7, 2019·Journal of Neuroinflammation·Song CaoHongxin Dong
Mar 28, 2017·Pain and Therapy·Joseph V PergolizziRobert B Raffa
Jun 30, 2019·International Journal of Molecular Sciences·Seoyon Yang, Min Cheol Chang
Oct 4, 2019·Pain Reports·Joyce T Da Silva, David A Seminowicz
Aug 3, 2017·Issues in Mental Health Nursing·Aude PaquetMurielle Girard
Jul 19, 2020·Journal of Gastroenterology·Ellyn DunbarUNKNOWN NAPS2 study group
Oct 30, 2018·Current Osteoporosis Reports·Joshua Havelin, Tamara King
Nov 19, 2020·PloS One·Benjamin LecorpsDaniel M Weary
Nov 15, 2020·Journal of Neuroscience Methods·Cynthia AbboudMarc Landry
Oct 18, 2019·Neuroscience and Biobehavioral Reviews·Inge TimmersLaura E Simons
Mar 20, 2019·Neuroscience and Biobehavioral Reviews·Anke Tappe-TheodorMichael M Morgan

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