Positive end-expiratory pressure (PEEP) during anaesthesia for the prevention of mortality and postoperative pulmonary complications

The Cochrane Database of Systematic Reviews
Georgina ImbergerAnn Merete Møller


General anaesthesia causes atelectasis which can lead to impaired respiratory function. Positive end-expiratory pressure (PEEP) is a mechanical manoeuvre which increases functional residual capacity (FRC) and prevents collapse of the airways thereby reducing atelectasis. It is not known whether intra-operative PEEP alters the risk of postoperative mortality and pulmonary complications. To assess the benefits and harms of intraoperative PEEP, for all adult surgical patients, on postoperative mortality and pulmonary outcomes. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 4), MEDLINE (via Ovid) (1966 to January 2010), EMBASE (via Ovid) (1980 to January 2010), CINAHL (via EBSCOhost) (1982 to January 2010), ISI Web of Science (1945 to January 2010) and LILACS (via BIREME interface) (1982 to January 2010). We included randomized clinical trials that evaluated the effect of PEEP versus no PEEP, during general anaesthesia, on postoperative mortality and postoperative respiratory complications. We included studies irrespective of language and publication status. Two investigators independently selected papers, extracted data that fulfilled our outcome criteria and assessed the...Continue Reading


Mar 31, 2011·Langenbeck's Archives of Surgery·Marian GradeB Michael Ghadimi
Jun 13, 2014·The Cochrane Database of Systematic Reviews·Fabiano T BarbosaCélio F de Sousa-Rodrigues
Oct 12, 2012·World Journal of Surgery·J NygrenInternational Association for Surgical Metabolism and Nutrition (IASMEN)
Dec 12, 2012·Anaesthesia·L D Gray, C Morris

Related Concepts

General Anesthesia
Compression Pulmonary Atelectasis
Experimental Lung Inflammation
Positive End-Expiratory Pressure
Postoperative Complications
Respiratory Failure
Anesthesia Procedures
Clinical Investigators

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