Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment

Journal of Applied Physiology
Luciana L FariasPatricia R M Rocco

Abstract

This study tests the hypotheses that a recruitment maneuver per se yields and/or intensifies lung mechanical stress. Recruitment maneuver was applied to a model of paraquat-induced acute lung injury (ALI) and to healthy rats with (ATEL) or without (CTRL) previous atelectasis. Recruitment was done by using 40-cmH(2)O continuous positive airway pressure for 40 s. Rats were, then, ventilated for 1 h at zero end-expiratory pressure (ZEEP) or positive end-expiratory pressure (PEEP; 5 cmH(2)O). Atelectasis was generated by inflating a sphygmomanometer around the thorax. Additional groups did not undergo recruitment but were ventilated for 1 h under ZEEP. Lung resistive and viscoelastic pressures and static elastance were computed before and immediately after recruitment, and at the end of 1 h of ventilation. Lungs were prepared for histology. Type III procollagen (PCIII) mRNA expression in lung tissue was analyzed by RT-PCR. Lung mechanics improved after recruitment in the CTRL and ALI groups. One hour of ventilation at ZEEP increased alveolar collapse, static elastance, and lung resistive and viscoelastic pressures. Alveolar collapse was similar in ATEL and ALI, and recruitment opened the alveoli in both groups. ALI showed higher PC...Continue Reading

References

Jan 1, 1992·Intensive Care Medicine·B Lachmann
May 1, 1991·The American Review of Respiratory Disease·K TsunoT Morioka
Dec 1, 1989·Journal of Applied Physiology·T SimilowskiJ Milic-Emili
Jul 1, 1988·Journal of Applied Physiology·J H BatesJ J Fredberg
Jan 1, 1988·Journal of Applied Physiology·T KochiJ Milic-Emili
Jun 1, 1985·Journal of Applied Physiology·J H BatesJ Milic-Emili
Jul 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J P Mortola, A Noworaj
Jul 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H K Chang, J P Mortola
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·L GattinoniF Valenza
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·J G MuscedereA S Slutsky
Feb 1, 1996·Journal of Applied Physiology·T NagaseM S Ludwig
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·M TakataK Miyasaka
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·A N ChesnuttJ G Clark
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·L GattinoniA Lissoni
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·P PelosiL Gattinoni
Apr 8, 1999·British Journal of Anaesthesia·H U RothenG Hedenstierna
May 1, 1999·Journal of Structural Biology·N Volkmann, D Hanein
May 18, 1999·British Journal of Anaesthesia·G TusmanB Lachmann
Jul 29, 1999·Chest·A S Slutsky
Sep 3, 1999·British Journal of Anaesthesia·H U RothenG Hedenstierna
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·L ArmstrongA B Millar
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·T E KlootA Nahum
Feb 15, 2001·Respiratory Care Clinics of North America·R M Kacmarek, D R Schwartz
May 25, 2001·Current Opinion in Critical Care·R M Kacmarek
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·J C RichardL Brochard
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·P R RoccoW A Zin
Feb 14, 2002·Journal of Applied Physiology·Edgardo D'AngeloJoseph Milic-Emili
Apr 27, 2002·Pflügers Archiv : European journal of physiology·Débora S OrnellasMarcelo M Morales
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Rolf D Hubmayr
Aug 7, 2002·Critical Care Medicine·Gee Young SuhO Jung Kwon
Sep 10, 2002·Anesthesiology·Muneyuki TakeuchiRobert M Kacmarek
Sep 28, 2002·Critical Care Medicine·Nahit CakarAvi Nahum
Nov 16, 2002·Journal of Applied Physiology·Anastacia M BilekDonald P Gaver
Dec 17, 2002·Respiratory Care Clinics of North America·Lluis BlanchJosefina Lopez-Aguilar
Jan 25, 2003·Critical Care Medicine·Jean-Christophe RichardGuy Bonmarchand
Feb 13, 2003·Journal of Clinical Monitoring and Computing·G Hedenstierna, H U Rothen
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Jeffrey M HalterGary F Nieman

❮ Previous
Next ❯

Citations

Sep 11, 2008·British Journal of Anaesthesia·N Soni, P Williams
Dec 17, 2008·Journal of Applied Physiology·Scott P AlbertGary F Nieman
Nov 23, 2006·Critical Care : the Official Journal of the Critical Care Forum·Alba B Souza-FernandesPatricia R M Rocco
Feb 23, 2007·Critical Care : the Official Journal of the Critical Care Forum·Maria-Eudóxia Pilotto de CarvalhoDaniel Deheinzelin
Mar 26, 2009·Critical Care : the Official Journal of the Critical Care Forum·Marc LickerJean-Marie Tschopp
Mar 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Paolo PelosiPatricia R M Rocco
Jan 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Anup DasJonathan G Hardman
Jul 16, 2015·Revista do Colégio Brasileiro de Cirurgiões·Cíntia Lourenço SantosAlberto Schanaider
Jun 6, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C S N B GarciaP R M Rocco
May 17, 2017·Hospital Practice·Oleg Epelbaum, Wilbert S Aronow
Mar 8, 2014·Expert Review of Respiratory Medicine·Yuda SutherasanPaolo Pelosi
Dec 20, 2007·Critical Care Medicine·Cristiane Sousa Nascimento Baez GarciaPatricia Rieken Macedo Rocco
Sep 8, 2010·Critical Care Medicine·Viviane R SantiagoPatricia R M Rocco
Nov 10, 2006·Current Opinion in Anaesthesiology·Ron Dueck
Feb 12, 2008·Intensive Care Medicine·Paolo Pelosi, Patricia R Rocco
Jan 16, 2008·Current Opinion in Critical Care·Paolo Pelosi, Daniela Negrini
Jun 17, 2010·Annals of Biomedical Engineering·Baoshun Ma, Jason H T Bates
Jun 16, 2010·Der Anaesthesist·M DavidK Markstaller
May 16, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gilman B AllenJason H T Bates
May 23, 2008·Critical Care Medicine·Douglas R RivaPatricia R M Rocco
Mar 8, 2012·Current Opinion in Anaesthesiology·Patricia R M RoccoPaolo Pelosi
Dec 14, 2012·Current Opinion in Anaesthesiology·Giorgio Della Rocca, Cecilia Coccia
Jul 17, 2013·European Journal of Anaesthesiology·Javier García-FernándezGöran Hedenstierna
Sep 6, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nadine BrewRichard Harding
Apr 19, 2016·Applied Neuropsychology. Adult·Umberto León-DomínguezJosé León-Carrión
Jul 16, 2015·International Journal of Injury Control and Safety Promotion·Erica Donnelly-Swift, Alan Kelly
Feb 12, 2008·Acta Anaesthesiologica Scandinavica·S-C KoA S Slutsky
Jun 11, 2009·British Journal of Pharmacology·Eleni Papakonstantinou, George Karakiulakis
Nov 9, 2017·Medizinische Klinik, Intensivmedizin und Notfallmedizin·F F CruzP Pelosi
May 26, 2018·Critical Care : the Official Journal of the Critical Care Forum·Gary F NiemanNader M Habashi
Jul 28, 2010·Expert Review of Respiratory Medicine·Patricia R M RoccoMarcelo Gama de Abreu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Patricia R M RoccoWalter A Zin
American Journal of Respiratory and Critical Care Medicine
D Dreyfuss, G Saumon
© 2021 Meta ULC. All rights reserved