PMID: 7542177Jul 1, 1995Paper

Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene

Carcinogenesis
S I MitsunagaA J Klein-Szanto

Abstract

Squamous cell carcinomas (SCCs) of the mouse skin, as well as several types of preinvasive carcinoma precursor lesions, were produced by complete carcinogenesis protocols with benzo[a]pyrene (B[a]P). Groups of mice were studied histologically at several time points. Tumors and precursor lesions were systematically counted on microscope slides. The main feature of tumor development using this ubiquitous human carcinogen was the sequential appearance of in situ flat lesions with progressive degrees of dysplasia. These changes, preceding the development of SCCs, were observed 20 weeks after beginning the carcinogen treatments. At this time point, in situ lesions outnumbered SCC approximately 10:1 at the higher total carcinogen dose examined. Ten weeks later, this ratio was approximately 1:1. With the lower total carcinogen dose protocol, progression was delayed since at 27 weeks preinvasive lesions outnumbered SCCs approximately 8:1. In addition to the in situ lesions, papillomas and keratoacanthomas were noted with the high B[a]P dose protocol, but tended to disappear at the end of the experiment, also indicating their probable role as SCC precursors. A study of histochemical markers showed that gamma-glutamyltranspeptidase (GGT)...Continue Reading

Citations

Feb 25, 2014·TheScientificWorldJournal·C BenazziF Gärtner
Jan 1, 1997·Japanese Journal of Cancer Research : Gann·E M YoussefS Fukushima
Nov 21, 1998·Veterinary Pathology·K A Schafer
Oct 29, 2005·Molecular Cancer Research : MCR·Zhongqiu ZhangMing You

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