Positive inotropic responses of the sodium channel modulator BDF 9148 in diseased rat myocardium

Clinical and Experimental Pharmacology & Physiology
A HoeyL Brown

Abstract

1. This study has defined the positive inotropic responses to the sodium channel modulator BDF 9148 in rats with hypertension, thyroid dysfunction, diabetes or dwarfism. Concentration-response curves to BDF 9148 and calcium chloride were determined in isolated left atria and left ventricular papillary muscles. 2. BDF 9148 increased force of contraction in left ventricular papillary muscles in all disease states with maximal responses comparable to calcium chloride. BDF 9148 potency was significantly decreased in muscles from diabetic rats only. 3. BDF 9148 produced similar responses in left atria except from hyperthyroid rats where negative inotropic responses only were measured. This exception confirms that the left atria is an imperfect model for ventricular responsiveness. 4. Thus, the increase in force of contraction in the ventricles as a consequence of sodium channel modulation by BDF 9148 is maintained in these disease states unlike responses to alpha-or beta-adrenoceptor agonists.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I KomuroS Izumo
Apr 1, 1991·Journal of Molecular and Cellular Cardiology·R H SchwingerE Erdmann
Nov 1, 1991·Clinical and Experimental Pharmacology & Physiology·L BrownP Fletcher
Jun 1, 1991·Clinical and Experimental Pharmacology & Physiology·J Ludbrook
Jul 1, 1986·Cardiovascular Research·L BrownE Erdmann
Mar 1, 1989·Journal of Pharmacological Methods·M BöhmE Erdmann
Oct 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·M BöhmE Erdmann
Sep 1, 1993·Journal of Cardiovascular Pharmacology·C MarchantC Sernia
Aug 1, 1994·Journal of Cardiovascular Pharmacology·G AmosL Brown
Oct 1, 1994·Journal of Cardiovascular Pharmacology·R NankervisL Brown
Sep 1, 1994·Clinical and Experimental Pharmacology & Physiology·L BrownB Miller
Nov 1, 1994·Clinical and Experimental Pharmacology & Physiology·S DoggrellL Brown
Jan 20, 1994·Biochemical Pharmacology·L BrownC Sernia
Aug 1, 1993·Circulation Research·S C Dudley, C M Baumgarten
Oct 1, 1993·Journal of the American College of Cardiology·M Packer

❮ Previous
Next ❯

Citations

Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·V Nand, S A Doggrell
Apr 16, 2003·Anaesthesia·J P NicholsonI K Driver

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.