Positive ion transmission mode ion/ion reactions in a hybrid linear ion trap

Analytical Chemistry
Jin WuS A McLuckey

Abstract

A triple quadrupole mass spectrometer capable of ion trapping experiments has been adapted for ion/ion reaction studies. The instrument is based on a commercially available linear ion trap (LIT) tandem mass spectrometer (i.e., an MDS SCIEX 2000 Q TRAP) that has been modified by mounting an atmospheric sampling glow discharge ionization (ASGDI) source to the side of the vacuum manifold for production of singly charged anions. The ASGDI source is located line of sight to the side of the third quadrupole of the triple quadrupole assembly (Q3). Anions are focused into the side of the rod array (i.e., anion injection occurs orthogonal to the normal ion flight path). A transmission mode method to perform ion/ion reactions has been developed whereby positive ions are transmitted through the pressurized collision quadrupole (Q2) while anions are stored in Q2. The Q2 LIT is used to trap negative ions whereas the Q3 LIT is used to accumulate positive ions transmitted from Q2. Anions are injected to Q3 and transferred to Q2, where they are stored and collisionally cooled. Multiply charged protein/peptide ions, formed by electrospray, are then mass selected by the first quadrupole assembly (Q1) operated in the rf/dc mode and injected into ...Continue Reading

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Citations

Apr 23, 2013·Journal of the American Society for Mass Spectrometry·Christian K FreseAlbert J R Heck
Apr 24, 2013·Journal of the American Society for Mass Spectrometry·Christopher M RoseJohn E P Syka
Jan 18, 2005·Journal of the American Society for Mass Spectrometry·Yu XiaJames W Hager
Sep 27, 2005·Journal of the American Society for Mass Spectrometry·Yu XiaScott A McLuckey
Nov 15, 2006·Journal of the American Society for Mass Spectrometry·Xiaorong LiangScott A McLuckey
Mar 14, 2007·Journal of the American Society for Mass Spectrometry·Xiaorong Liang, Scott A McLuckey
Dec 18, 2007·Journal of the American Society for Mass Spectrometry·Yu Xia, Scott A McLuckey
Oct 8, 2008·Journal of the American Society for Mass Spectrometry·Matthew W SoykEthan R Badman
Jun 6, 2009·Journal of the American Society for Mass Spectrometry·Qin ZhaoEthan R Badman
Jul 2, 2010·The Review of Scientific Instruments·Matthew J MyerAllison S Danell
Jan 7, 2009·Rapid Communications in Mass Spectrometry : RCM·Joshua F EmoryScott A McLuckey
Sep 2, 2015·Journal of the American Society for Mass Spectrometry·Kenneth J Laszlo, Matthew F Bush
Apr 15, 2015·Journal of the American Society for Mass Spectrometry·Dan GuoWei Xu
Dec 15, 2016·Journal of the American Society for Mass Spectrometry·Avinash A PatilWen-Ping Peng
Apr 3, 2009·Journal of the American Society for Mass Spectrometry·Mircea Guna, Thomas A Biesenthal
Dec 22, 2012·Chemical Communications : Chem Comm·Boone M Prentice, Scott A McLuckey
May 17, 2017·Journal of the American Society for Mass Spectrometry·Sy-Chyi ChengJentaie Shiea

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