PMID: 25785098Mar 19, 2015Paper

Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer

International Journal of Clinical and Experimental Medicine
Yunfei GeYinlu Ding

Abstract

Metastasis-associated in colon cancer-1 (MACC1), a new gene associated with primary and metastatic colon cancer, promotes tumor cell growth as well as the development of distant metastasis. The aim of this study is to investigate the expression of MACC1 protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis. Expression of MACC1 protein was detected immunohistochemically in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between MACC1 protein expression and clinicopathological parameters, postoperative liver metastasis were analyzed. Immunohistochemistry examination showed that MACC1 protein expression was significantly more abundant in colon cancer tissues than in normal colon tissues (P = 0.038), Positive rate of MACC1 expression in colon cancer tissues was increased significantly in patients with lymph node metastases (P = 0.001) and higher T stages (P = 0.006). Postoperative live metastasis-free survival period was significantly longer in negative MACC1 expression group than that of positive MACC1 expression group (36.4 ± 2.85 vs. 28.6 ± 2.02 months, P = 0.014). Multivariate analysis showed that MACC1 expression level is an independent prognost...Continue Reading

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