Positive pediatric exercise capacity trajectory predicts better adult Fontan physiology rationale for early establishment of exercise habits

International Journal of Cardiology
H OhuchiMichikazu Nakai

Abstract

Exercise training is recommended for its possible favorable effects on Fontan pathophysiology. This study aimed to elucidate the impact of pediatric exercise capacity trajectory, which may mimic the effect of exercise training, on late adult Fontan pathophysiology. Since 1990, 97 Fontan patients had consecutively undergone two serial cardiopulmonary exercise tests (CPX1 and CPX2) during childhood (ages 8 ± 2 and 14 ± 2 years) and one during adulthood (CPX3; age 23 ± 5 years). The changes in peak oxygen uptake (PVO2: % of normal value) from CPX1 to CPX2 (1-dPVO2) and from CPX2 to CPX3 (2-dPVO2) were calculated, and then the patients were divided into four subgroups according the 1-dPVO2 and 2-dPVO2. In their adulthood, when compared with groups with negative 1-dPVO2, the central venous pressure, plasma brain natriuretic peptide level, and renal resistive index were lower, whereas liver synthetic function, body fat-free percentage, and PVO2 were higher in those with positive 1-dPVO2 (p < 0.05-0.0001). However, these favorable associations of 2-d-PVO2 with adult Fontan pathophysiology were not observed, except for the PVO2. After CPX3, 13 unexpected events occurred, and the risk was 76% lower in the groups having positive 1-dPVO2 ...Continue Reading

Citations

Apr 16, 2020·Journal of the American Heart Association·Derek TranRachael Cordina
Jul 29, 2020·European Journal of Preventive Cardiology·Linda E ScheffersWim A Helbing
Nov 7, 2019·Heart Failure Reviews·Danielle S BursteinAlexander R Opotowsky
May 20, 2020·Therapeutic Advances in Chronic Disease·Miriam MichelKai Thorsten Laser
Dec 9, 2020·Journal of the American Heart Association·Adam W PowellAlexander R Opotowsky
Apr 12, 2019·Journal of Functional Morphology and Kinesiology·Vito PavoneAntonino Bianco

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