Positive photobiological investigation in reticular erythematous mucinosis syndrome

Photodermatology, Photoimmunology & Photomedicine
H AdamskiJ Chevrant-Breton

Abstract

Reticular erythematous mucinosis (REM) syndrome is a rare disorder. Its clinical course is cyclic with remissions and exacerbations. In this disease, photosensitivity has previously been noticed but rarely demonstrated. We report three new cases with positive photobiological investigation. Three patients (two males, one female) with a mean age 47 years were seen with reticular erythematous papules on the upper chest and or back. After sun exposure, the lesions were exacerbated. Skin biopsies showed dermal lymphocytic perivascular infiltration with mucin deposition between collagen bundles. Direct immunofluorescence was negative. Antinuclear antibodies were absent. In cabin, ultraviolet (UV)A exposure reproduced clinically and histologically REM lesions in our cases. UVA and UVB provocating phototests were negative. In all patients treatment with oral antimalarials and external photoprotection was effective. In our patients, we confirm the photosensitive feature of REM syndrome by provocative irradiation in UVA cabin. The mechanism of triggering is actually unclear. It is supposed that UV radiation, heat, and perspiration are necessary to reveal this affection.

References

Nov 1, 1979·Archives of Dermatology·W L MorisonJ A Parrish
Aug 1, 1992·Journal of the American Academy of Dermatology·L LoweT M Johnson
Jan 1, 1987·Clinical and Experimental Dermatology·H J DoddA Sadrudin
Aug 1, 1974·The British Journal of Dermatology·G K SteiglederU Linker
Apr 16, 1998·Clinical and Experimental Dermatology·J Del PozoE Fonseca
Jun 26, 2001·Journal of the American Academy of Dermatology·A KuhnP Lehmann
Dec 1, 1960·Archives of Dermatology·H O PERRYH MONTGOMERY

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Citations

Jul 14, 2012·International Journal of Dermatology·Sumeet TharejaNeil A Fenske
Aug 21, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·A Amherd-HoekstraG F L Hofbauer
Jan 26, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·T AtciC Baykal
Jul 30, 2014·The American Journal of Dermatopathology·José M Mir-BonaféAngel Santos-Briz

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