Positive regulation of humoral and innate immune responses induced by inactivated Avian Influenza Virus vaccine in broiler chickens

Veterinary Research Communications
Fatma Abdallah, Ola Hassanin

Abstract

Avian Influenza (AI) vaccines are widely used for mammals and birds in a trial to eliminate the Avian Influenza virus (AIV) infection from the world. However and up till now the virus is still existed via modulation of its antigenic structure to evade the pressure of host immune responses. For a complete understanding of the immune responses following AI vaccination in chickens, the modulations of the chickens humoral immune responses and interferon-alpha signaling pathway, as a fundamental part of the innate immune responses, were investigated. In our study, we measured the humoral immune response using hemagglutination-inhibition (HI) and enzyme-linked immunosorbent assay (ELISA) tests. In addition, chicken interferon-alpha pathway components was measured at RNA levels using Quantitative Real-time PCR (qRT-PCR) following one dose of inactivated H5N1 influenza vaccine at 14 days of age. In this study, the protective levels of humoral antibody responses were observed at 14, 21 and 28 days following immunization with inactivated (Re-1/H5N1) AI vaccine. In the chicken spleen cells, up regulation in the chicken interferon-alpha pathway components (MX1 & IRF7) was existed as early as 48 h post vaccination and remained until 28 days...Continue Reading

References

Oct 3, 1999·Veterinary Immunology and Immunopathology·B LambrechtT P van den Berg
Jul 22, 2009·Revue Scientifique Et Technique·O HallerG Kochs
Feb 19, 2011·Avian Pathology : Journal of the W.V.P.A·Riks MaasSandra Venema
Mar 23, 2011·Biochemical Pharmacology·John Unitt, David Hornigold
Jun 24, 2011·Veterinary Immunology and Immunopathology·Fabienne RauwBénédicte Lambrecht
Mar 2, 2013·Journal of Virology·Lindomar PenaDaniel R Perez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.